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We’ve compiled a short guide to choosing a strategy for your next Cre-lox conditional knockout (cKO) model which you can download here. Compared with standard knockout models a cKO has much greater flexibility, for example by enabling tissue-specific knockout of your target gene. As with any genetic modification the right design is crucial and must […]
6 Facts You May Not Know About Cre-Lox The basics of conditional knockout mice are familiar to any researcher who uses mouse models, even if this model type isn’t yet a part of your research. Using the Cre-lox system in an experiment seems simple: two lines are crossed, one with tissue-specific expression of Cre and […]
Inducible Control of Your Tissue-Specific Animal Model The Cre-lox system is commonly used to provide tissue-specific gene knockout. In order for this to happen in vivo, two mouse lines are mated together – The tissue-specific Cre line and a second mouse line containing your gene of interest flanked by loxP sites (floxed mouse). Cre recombines […]
Begin your custom animal model in 3, 2, 1… Gene of interest? Check. Model type? Check. Species and strain? Check. Great, let’s get started! When you are ready to start a custom animal model project with us, we’re ready to move your project forward, too. Step 1: Sign your project quote and let your sales […]
Conventional KO Mouse Model Brings Client Success Dr. Vadim Arshavsky, Scientific Director of the Albert Eye Research Institute at Duke University, was one of ingenious targeting laboratory’s very first clients. In 1999, ingenious generated a Phosducin knockout mouse model for Dr. Arshavsky, who had just started his lab at Harvard University a few years prior. […]
A Detailed Analysis of the Price and Value of Knockout Mouse Models According to a recent report on the pricing analysis of knockout mouse models, there are many more factors involved in determining the monetary value of the mice, aside from the importance of the research studies they are used in. Demand, availability, the complexity […]
New Insight on the Effects of the ARMC5 Gene on Patients Suffering from Cushing’s Syndrome Genetic experiments and knockout mice have recently helped scientists at the University of Montreal Hospital Research Centre (CRCHUM) gain new insight on the effects that eliminating a specific gene known as ARMC5 can have in inducing particular ailments and predispositions […]
Scientists Discover a Faster and More Accurate Method of Studying the Circadian Rhythm Nearly all animals that follow a 24-hour cycle are subject to the famous circadian rhythms – the physiological shifts that regulate our biology at a cellular level. These inner biological clocks are affected by numerous genetic factors that have a strong impact […]
The Study of RILF Through a Genetically Modified Murine Mouse Model While studying RILF (reversible infantile liver failure), a mitochondrial disease that can cause severe unbalance in liver functions during infancy, scientists in Japan have found that they can explore the mechanisms involved with the progress of the condition through the use of a new […]
Cardiac Knockout Mice Show Role of Gene in Fat Metabolism Scientists know that the heart predominantly uses lipids as fuel in order to function. However, recent research conducted by molecular biologist Dr. Weiqin Chen of Augusta University seems to reveal that both too many and too few of the lipid droplets required for normal heart […]