Knockout Mouse Models

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Knockout Mice

A knockout mouse is a mouse in which an existing gene has been inactivated, or “knocked out,” by deleting portions of the gene’s DNA sequence to make it nonfunctional, or by replacing the gene with an altered DNA sequence.  ingenious began as one of the pioneering companies delivering knockout mice to researchers worldwide. From conventional deletions to conditional knockouts and large scale deletions using BACs, we have developed the technology and expertise to target even the most challenging genes. Working with ingenious targeting laboratory, our clients know they have chosen a company with longevity, backed by almost two decades of successful, published experience with knockout mice.

Work with ingenious
for your custom knockout mouse model and enjoy:

Certainty

The model you design is the model we deliver.

Guaranteed delivery

Assurance of your mouse model, not just your money back.

Value

Our proprietary technologies save time and money.


Learn more about ingenious’ core knockout specialties:



  • Delete as little as 200bp, or as much as 200kb using our BAC technology.

  • Enhance the versatility of your knockout mice by combining reporter gene expression with your targeted knockout.


knockout mouse

The target region is deleted or replaced with a reporter gene. The targeted gene is thus inactivated at all times, in all tissues.

knockout mouse

The target region is flanked by loxP sites (“floxed”) to facilitate Cre recombinase-mediated excision, leading to tissue-specific gene inactivation.



Cre-Lox Facts

6 Facts You May Not Know About Cre-Lox By Richard Row, PhD The basics of conditional knockout mice are familiar to any researcher who uses mouse models, even if this model type isn’t yet a part of your research. Using the Cre-lox system in an experiment seems simple: two lines are crossed, one with tissue-specific

Gaining Inducible Control

Inducible control of your tissue-specific animal model by Kristen Couglin The Cre-lox system is commonly used to provide tissue-specific gene knockout.  In order for this to happen in vivo, two mouse lines are mated together – The tissue-specific Cre line and a second mouse line containing your gene of interest flanked by loxP sites (floxed

A Conditional Knockout That Took Research Further

The right myopathy model After years of work in in vitro systems and cultured cells your research may reach a point where an animal model is required. This major transition requires a new mindset, and consideration of factors that didn’t previously affect experiments. When evaluating genetically modified animal models each stage of their life must

“I am very happy with iTL’s mouse knockout services. It was pleasant to collaborate with my project manager. She was very thorough and communicative, an excellent combination. I will certainly use iTL again when needed, and I’m happy to share my positive experience with colleagues.”

-John Creemers, PhD