Knockout Mouse Models

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KO mice by ingenious
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Knockout Mice

A knockout mouse is a mouse in which an existing gene has been inactivated, or “knocked out,” by deleting portions of the gene’s DNA sequence to make it nonfunctional, or by replacing the gene with an altered DNA sequence.  ingenious began as one of the pioneering companies delivering knockout mice to researchers worldwide. From conventional deletions to conditional knockouts and large scale deletions using BACs, we have developed the technology and expertise to target even the most challenging genes. Working with ingenious, our clients know they have chosen a company with longevity, backed by almost two decades of successful, published experience with knockout mice.

Work with ingenious
for your knockout mouse model and enjoy:


The model you design is the model we deliver.

Guaranteed delivery

Assurance of your mouse model, not just your money back.


Our proprietary technologies save time and money.

Learn more about ingenious’ core knockout specialties:

  • Delete as little as 200bp, or as much as 200kb using our BAC technology.

  • Enhance the versatility of your knockout mice by combining reporter gene expression with your targeted knockout.

knockout mouse

The target region is deleted or replaced with a reporter gene. The targeted gene is thus inactivated at all times, in all tissues.

knockout mouse

The target region is flanked by loxP sites (“floxed”) to facilitate Cre recombinase-mediated excision, leading to tissue-specific gene inactivation.

How do I start my custom model project?

Begin your custom animal model in 3, 2, 1…   Gene of interest? Check. Model type? Check. Species & strain? Check. Great, let’s get started! When you are ready to start a custom animal model project with us, we’re ready to move your project forward, too. Step 1: Sign your project quote and let your

Recent Client Publications!

Congratulations to our Clients Congratulations to our Clients Dr. Douglas Gould from UCSF School of Medicine, Dr. Ichizo Nishino from National Institute of Neuroscience, Japan, & Dr. Jian-xing Ma from University of Oklahoma Health Sciences Center. Their research and publications included the use of conditional knockout models, and point mutation knockin mouse models from ingenious. They now are among the hundreds

The Value of Knockout Mouse Models

“I am very happy with iTL’s mouse knockout services. It was pleasant to collaborate with my project manager. She was very thorough and communicative, an excellent combination. I will certainly use iTL again when needed, and I’m happy to share my positive experience with colleagues.”

-John Creemers, PhD