What APP Knockin mouse models are available?

When APP Knockin lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is APP knockout embryonic lethal in mice?

It depends on background and allele design. Some APP germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live APP animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for APP?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●2 Models Available

APP Knockin mouse models

Name: APP-PSEN1(U)
Brand: ingenious targeting laboratory
SKU: KI 233917
Availability: InStock

Browse 2 APP mouse models including knockin variants — in stock and ready to ship from ingenious targeting laboratory. Request a quote within 24 hours.

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What APP mouse models are available?

ingenious targeting laboratory offers 2 distinct APP (APP) catalog mouse models, featuring knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model Availability	Allele Class Options	Quality Control Standards
2 Ready Catalog Lines	Conditional Knockout (cKO) on request	Documented Germline Transmission
Custom Model Generation	Constitutive Knockout (KO) on request	Strict United States QC Guidelines
Advanced Modifications	Humanized, Knockin, Transgenic	Cryo or Live Dispatch Options

Quality Control: Documented Germline Transmission
Quality Control: Strict United States QC Guidelines
Quality Control: Cryo or Live Dispatch Options

APP model types

PathAvailability

Knockout
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Conditional knockout
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Knockin
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Humanized
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Transgenic / overexpression
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Prefer the order form? Order. Need an allele that is not listed? Request a quote.

APP allele types

Knockout, conditional, knockin, humanized, and related paths for APP (human APP). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Conventional / global / constitutive KO

Conditional KO (floxed / loxP)

Inducible conditional KO (CreER / tet)

Tissue specific KO

Specify tissue or Cre driver on quote

Knockout first (tm1a / IKMC)

Convertible floxed allele pathway

Double / compound KO

Multi allele / compound knockout project

Large scale / BAC deletion

BAC scale deletion or targeting

Knockin

Point mutation KI

cDNA KI

Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)

Tag KI (FLAG, HA, Myc, V5)

Conditional KI (e.g. Rosa26 LSL)

LSL or conditional expression knockin

Gene replacement KI

Humanized

Full gene replacement

Partial / domain humanized

Domain or partial humanization scope

Immune checkpoint humanized

Checkpoint IO humanization when gene is a checkpoint target

Single humanized

Double / multi humanized

Multi humanized / combination IO project

Transgenic

Random integration transgenic

Safe harbor (ROSA26, HPRT, H11, Col1a1)

Overexpression transgenic

BAC transgenic

BAC transgenic or large fragment insert

Cre / recombinase

Constitutive Cre driver

Inducible Cre (CreER / tet)

Tamoxifen or dox inducible Cre

Dual recombinase (Cre+Dre / Cre+Flp)

Dual recombinase breeding scheme

Flp driver

Flp or FRT derivative allele pairing

Reporter

Reporter knockin (gene specific)

Standalone reporter catalog (lineage tracing, constitutive, dual reporter)

Catalog reporter lines not tied to a single gene allele

Species / background

Rat KO / KI / transgenic

Specify rat on quote

Rabbit models

Specify rabbit on quote

C57BL/6 (B6J / B6N)

Background substrain on quote

BALB/c

129, NOD, NSG, FVB, CD1, DBA/2

Background strain on quote

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

Ready to ship

Search 14,774 strains. Many ship from live colonies.

Browse by gene, model type, or therapeutic area. Live colonies available for many top requested knockouts, knockins, and humanized lines.

Trp53Tumor suppressor, knockout & knockin Brca1Breast cancer model, multiple alleles Rosa26Safe harbor for reporters & cassettes

Browse Full Catalog

Model generation

Need a knockout, knockin, or humanized line?

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 100% germline transmission guarantee.

Conventional and conditional knockouts
Point mutation and humanized knockins
2,800+ models generated since 1998

Request a Quote Explore model generation services

Available APP catalog models

2 APP lines with QC documentation and technical support.

APP-PSEN1(P)
Knockin
disease model mice,regular mice
liveKI 233918
Order
APP-PSEN1(U)
Knockin
disease model mice,regular mice
liveKI 233917
Order

Selected publications from ingenious targeting laboratory

Peer reviewed work involving APP from ITL supported projects.

Spatial Mapping of CoQ10 Repletion by BPM31510 in a Genetic Mouse Model (Coq4F147C) of Coenzyme Q DeficiencyBarriocanal-Casado E, Stopka SA, Pesini A, Aristizabal-Henao JJ, Karmacharya S, Van Cura D, Zhang R, Nickerson KR, Grover K, Zavidij O, Wessel SR, Narain NR, Modur V, Gesta S, Kiebish MA, Quinzii CM. (2026). J Lipid Res. 3(67): 100987
Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic NeurodegenerationJiang Y, Sachdeva K, Goulbourne CN, Berg MJ, Peddy J, Stavrides PH, Pensalfini A, Pawlik M, Malampati S, Whyte L, Basavarajappa BS, Shivakumar S, Bleiwas C, Smiley JF, Mathews PM, Nixon RA. (2025). . J Neurosci 29(45): e2331242025.
Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responsesAdelaja A, Taylor B, Sheu KM, Liu Y, Luecke S, Hoffmann A. (2021). Immunity 54(5): 916-930.e7
Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer’s DiseasePark G, Nhan HS, Tyan SH, Kawakatsu Y, Zhang C, Navarro M, Koo EH. (2020). Cell Rep 31(13): 107839
Multi-image color refinement with application to disparity estimationBishop, TE. (2018). US Patent No.10,097,805 B2

View all ITL publications

Looking for a APP mouse model?

We have 2 APP models in stock — including Knockin types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

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Models Available

Model Types

24 hrs

Quote Turnaround

Included

QC Documentation