Conventional / global / constitutive KO
●3 Models Available
Aim2 Conditional Knockout, Knockout mouse models
Browse 3 Aim2 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Aim2 conditional knockout mouse, Aim2 knockout mouse. Request a quote within 24 hours.
Why model Aim2
Aim2, the mouse ortholog of human AIM2, encodes an interferon-inducible HIN-200 family sensor that pairs an N-terminal pyrin domain with a C-terminal HIN200 domain gripping the sugar-phosphate backbone of cytosolic double-stranded DNA in sequence-independent fashion. DNA binding relieves intramolecular autoinhibition, allowing pyrin domain filaments to nucleate ASC (Pycard) into a caspase-1 activating platform that matures pro-IL-1beta and pro-IL-18 and cleaves gasdermin D to drive pyroptosis, the core response to Francisella, cytomegalovirus, and self DNA released after genotoxic stress. Conditional nulls isolate cell-intrinsic sensing in macrophages, dendritic cells, or intestinal epithelium, whereas HIN200 point mutants that abolish DNA binding without removing protein separate sensing from scaffolding, and humanization supports inhibitor programs. Bear in mind the murine Ifi200 cluster contains Ifi202b, Ifi203, and Ifi204, which share HIN domains and can obscure phenotypes, while parallel Nlrp3 and Nlrc4 inflammasomes provide overlapping IL-1beta output, so pairing an allele with the right myeloid Cre and cytokine endpoint is essential.
What Aim2 mouse models are available?
ingenious targeting laboratory offers 3 distinct Aim2 (AIM2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Aim2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Aim2 allele types
Knockout, conditional, knockin, humanized, and related paths for Aim2 (human AIM2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Aim2 catalog models
3 Aim2 lines with QC documentation and technical support. Aim2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Aim2 (AIM2) from ITL supported projects.
- AIM2 inflammasome mediates apoptotic and pyroptotic death in the cerebellum following chronic hypoperfusionPoh L, Razak S, Lim HM, Lai MKP, Chen CL, Lim LHK, Arumugam TV, Fann DY. (2021). Exp Neurol346: 113856
- AIM2 Inflammasome Mediates Hallmark Neuropathological Alterations and Cognitive Impairment in a Mouse Model of Vascular DementiaPoh L, Fann DY, Wong P, Lim HM, Foo SL, Kang SW, Rajeev V, Selvaraji S, Vinaya RI, Parathy N, Khan MB, Jo DG, Drummond GR, Sobey CG, Lai MKP, Chen CLH, Lim LHK, Arumugam TV. (2021). Mol Psychiatry 26(8):4544-4560
- Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.Wilson JE, Petrucelli AS, Chen L, Koblansky AA, Truax AD, Oyama Y, Rogers AB, Brickey WJ, Wang Y, Schneider M, Mühlbauer M, Chou WC, Barker BR, Jobin C, Allbritton NL, Ramsden DA, Davis BK, Ting JP. (2015). Nat Med 21: 906-913
Looking for a Aim2 mouse model?
We have 3 Aim2 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Aim2 Mouse Model Types
A Aim2 knockout mouse has the Aim2 gene permanently inactivated, enabling loss of function studies. A Aim2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Aim2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Aim2 organized by modification type. Each URL is indexable and matches common search patterns.