Conventional / global / constitutive KO
●1 Model Available
Alk Knockout mouse model
Browse 1 Alk mouse model including knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Alk
Anaplastic lymphoma kinase is encoded by Alk, the mouse ortholog of human ALK, a single-pass receptor tyrosine kinase of the insulin receptor superfamily whose extracellular MAM, LDLa, and glycine-rich domains bind the ALKAL1 and ALKAL2 ligands to drive dimerization and trans-autophosphorylation, feeding RAS/MAPK, PI3K/AKT, and JAK/STAT3 output. Oncogenic activation follows two distinct routes: chromosomal fusions such as EML4-ALK and NPM1-ALK that impose ligand-independent oligomerization, and kinase domain substitutions including F1174L and R1275Q found in neuroblastoma. Allele choice should follow the question, since an inducible fusion knockin at the Alk locus interrogates fusion-driven lung or lymphoid tumorigenesis, a point-mutant knockin reproduces neuroblastoma predisposition, and ectodomain humanization supports antibody, conjugate, and CAR-T pharmacology alongside resistance modeling for L1196M or G1202R. Because Alk null animals are viable with only subtle neurobehavioral changes, constitutive nulls suit ligand-axis studies, while tumor endpoints demand a tissue-restricted Cre or inducible expression matched to the target lineage.
What Alk mouse models are available?
ingenious targeting laboratory offers 1 distinct Alk (ALK) catalog mouse model, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Alk model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Alk allele types
Knockout, conditional, knockin, humanized, and related paths for Alk (human ALK). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Alk catalog models
1 Alk line with QC documentation and technical support.
- Order
Alk-KO
KnockoutKO/CKO mice
embryo cryopreservationKO 200025
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Alk (ALK) from ITL supported projects.
- Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancerMaguire OA, Ackerman SE, Szwed SK, Maganti AV, Marchildon F, Huang X, Kramer DJ, Rosas-Villegas A, Gelfer RG, Turner LE, Ceballos V, Hejazi A, Samborska B, Rahbani JF, Dykstra CB, Annis MG, Luo JD, Carroll TS, Jiang CS, Dannenberg AJ, Siegel PM, Tersey SA, Mirmira RG, Kazak L, Cohen P. (2021). Cell Metab 33(3): 499-512.e6
- Allergic inflammation is initiated by IL-33-dependent crosstalk between mast cells and basophilsHsu CL, Chhiba KD, Krier-Burris R, Hosakoppal S, Berdnikovs S, Miller ML, Bryce PJ. (2020). PLoS One 15(1): e0226701
- Deletion of DDB1- and CUL4- associated factor-17 (Dcaf17) gene causes spermatogenesis defects and male infertility in miceAli A, Mistry BV, Ahmed HA, Abdulla R, Amer HA, Prince A, Alazami AM, Alkuraya FS, Assiri A. (2018). Sci Rep 8(1): 9202
- The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk CellsSavant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, Korn C, Valls AF, Benest AV, Terhardt D, Qu X, Adams RH, Baldwin HS, Ruiz de Almodovar C, Rodewald HR, Augustin HG. (2015). Cell Rep 12(11): 1761-73
- Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice.Min SH, Suzuki A, Stalker TJ, Zhao L, Wang Y, McKennan C, Riese MJ, Guzman JF, Zhang S, Lian L, Joshi R, Meng R, Seeholzer SH, Choi JK, Koretzky G, Marks MS, Abrams CS. (2014). Nat Commun 5: 4691
Looking for a Alk mouse model?
We have 1 Alk model available — including Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
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Model Types
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QC Documentation
About Alk Mouse Model Types
A Alk knockout mouse has the Alk gene permanently inactivated, enabling loss of function studies.
Modifications available
Jump to catalog backed pages for Alk organized by modification type. Each URL is indexable and matches common search patterns.