Conventional / global / constitutive KO
●11 Models Available
READY TO SHIP!
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Apoe Conditional Knockout, Knockout, Xenograft-Applicable mouse models
Browse 11 Apoe mouse models including conditional knockout, knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Apoe conditional knockout mouse, Apoe knockout mouse, Apoe xenograft-applicable mouse. Request a quote within 24 hours.
Why model Apoe
Apoe is the mouse ortholog of human APOE and encodes a 299 residue exchangeable apolipoprotein whose amino-terminal four-helix bundle presents the receptor binding surface for LDLR, LRP1 and heparan sulfate proteoglycans, while the carboxy-terminal domain mediates lipid binding and self-association, together directing clearance of chylomicron remnants and VLDL and controlling brain lipid and amyloid beta handling. Mouse Apoe resembles human APOE4 at the domain interaction level and lacks the human isoform series, so targeted replacement knockins carrying human APOE2, APOE3 or APOE4 coding sequence under the endogenous promoter are the only honest platform for isoform-dependent questions in Alzheimer disease, and they are routinely crossed to amyloid or tau models. Conventional null mice develop marked hypercholesterolemia and spontaneous atherosclerosis on chow, which remains the workhorse cardiovascular readout. Because Apoe and Apoj partially overlap in glial lipid transport, interpret CNS phenotypes with that in mind, and select humanized alleles when testing isoform-selective or ASO based therapeutics.
What Apoe mouse models are available?
ingenious targeting laboratory offers 11 distinct Apoe (APOE) catalog mouse models, featuring conditional knockout, standard knockout, and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 11 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Apoe model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Apoe allele types
Knockout, conditional, knockin, humanized, and related paths for Apoe (human APOE). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Apoe catalog models
11 Apoe lines with QC documentation and technical support. Apoe floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Apoe-Flox
CKOCKO, Disease Model
These mice carry loxP sites flanking exon 1-4 of Apoe When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Apoe gene.
LiveCKO 220617 - Order
Apoe-KO(2)
KOKO, Disease Model
Apoe-KO(2) mice (Stock No.KO 190565) carry a knockout allele derived from the targeted deletion of exon 2-4. While Apoe-KO mice (Stock No.KO 00033) have been pulled from shelves for some reasons.
LiveKO 190565 - Order
Apoe-KO(2)/Crbn-I391V
XAKO, Point Mutation
The Crbn-I391V (KI 200331) was crossed with Apoe-KO(2)(KO 190565) to generate Crbn-I391V/Apoe-KO(2) mice.
In DevelopmentXA 261456 - Order
Apoe-KO(2)/hGLP1R
XAKO, Target-Humanized
The hGLP1R (HU 200220) was crossed with Apoe-KO(2)(KO 190565) to generate hGLP1R/Apoe-KO(2) mice.
In DevelopmentXA 260939 - Order
Apoe-KO(2)/hCD47/hSIRPA(2)
XAKO, Target-Humanized
The Apoe-KO(2) (KO 190565) was crossed with hCD47/hSIRPA(2)(HU 2000111) to generate Apoe-KO(2)/hCD47/hSIRPA(2) mice.
LiveXA 241005 - Order
Apoe-KO(2)/hANGPTL3(4)
XAKO, Target-Humanized
The hANGPTL3(4) (HU 210036) was crossed with Apoe-KO(2)(KO 190565) to generate hANGPTL3(4)/Apoe-KO(2) mice.
LiveXA 242593 - Order
Apoe-KO(2)/hPCSK9
XAKO, Target-Humanized
The Apoe-KO(2) (KO 190565) was crossed with hPCSK9(HU 00075) to generate Apoe-KO(2)/hPCSK9 mice.
LiveXA 250813 - Order
Apoe-KO(2)/hAPOC3
XAKO, Target-Humanized
The Apoe-KO(2) (KO 190565) was crossed with hAPOC3(HU 225050) to generate Apoe-KO(2)/hAPOC3 mice.
Embryo CryopreservedXA 242592 - Order
Apoe-KO(2)/hCD47/hPCSK9(4)/hSIRPA(2)
XATarget-Humanized
The hPCSK9(4) (HU 251531) was crossed with Apoe-KO(2)/hCD47/hSIRPA(2)(XA 241005) to generate hPCSK9(4)/Apoe-KO(2)/hCD47/hSIRPA(2) mice.
In DevelopmentXA 263490 - Order
Apoe-KO/Nos3-KO
XAKO
The Apoe-KO(2)(KO 190565) was crossed with Nos3-KO(KO 18022) to generate Apoe-KO/Nos3-KO mice.
Sperm CryopreservedXA 242509 - Order
Apoe-KO(2)/hCD47
XAKO, Target-Humanized
The hCD47 (HU 00050) was crossed with Apoe-KO(2)(KO 190565) to generate hCD47/Apoe-KO(2) mice.
In DevelopmentXA 261532
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Apoe (APOE) from ingenious supported projects.
- Loss of SPRR3 in ApoE-/- mice leads to atheroma vulnerability through Akt dependent and independent effects in VSMCsLietman CD, Segedy AK, Li B, Fazio S, Atkinson JB, Linton MF, Young PP. (2017). PLoS One 12(9): e0184620
- NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3Hamblet CE, Makowski SL, Tritapoe JM, Pomerantz JL. (2016). J Immunol 196(6): 2614-26
- Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice.Zack M, Boyanovsky BB, Shridas P, Bailey W, Forrest K, Howatt DA, Gelb MH, de Beer FC, Daugherty A, Webb NR. (2011). Atherosclerosis 214: 58-64
Looking for a Apoe mouse model?
We have 11 Apoe models in stock — including Conditional Knockout, Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
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Model Types
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QC Documentation
About Apoe Mouse Model Types
A Apoe knockout mouse has the Apoe gene permanently inactivated, enabling loss of function studies. A Apoe conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Apoe, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Apoe organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Apoe.
Breed this line with ingenious targeting laboratory
Send the Apoe line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.