Conventional / global / constitutive KO
●8 Models Available
Apoe Conditional Knockout, Knockout, Xenograft-Applicable mouse models
Browse 8 Apoe mouse models including conditional knockout, knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Apoe conditional knockout mouse, Apoe knockout mouse, Apoe xenograft-applicable mouse. Request a quote within 24 hours.
Why model Apoe
Apoe is the mouse ortholog of human APOE and encodes a 299 residue exchangeable apolipoprotein whose amino-terminal four-helix bundle presents the receptor binding surface for LDLR, LRP1 and heparan sulfate proteoglycans, while the carboxy-terminal domain mediates lipid binding and self-association, together directing clearance of chylomicron remnants and VLDL and controlling brain lipid and amyloid beta handling. Mouse Apoe resembles human APOE4 at the domain interaction level and lacks the human isoform series, so targeted replacement knockins carrying human APOE2, APOE3 or APOE4 coding sequence under the endogenous promoter are the only honest platform for isoform-dependent questions in Alzheimer disease, and they are routinely crossed to amyloid or tau models. Conventional null mice develop marked hypercholesterolemia and spontaneous atherosclerosis on chow, which remains the workhorse cardiovascular readout. Because Apoe and Apoj partially overlap in glial lipid transport, interpret CNS phenotypes with that in mind, and select humanized alleles when testing isoform-selective or ASO based therapeutics.
What Apoe mouse models are available?
ingenious targeting laboratory offers 8 distinct Apoe (APOE) catalog mouse models, featuring conditional knockout, standard knockout, and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 8 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Apoe model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Apoe allele types
Knockout, conditional, knockin, humanized, and related paths for Apoe (human APOE). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Apoe catalog models
8 Apoe lines with QC documentation and technical support. Apoe floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Apoe-Flox
Conditional KnockoutKO/CKO mice, disease model mice
liveCKO 220617 - Order
Apoe-KO(2)
KnockoutKO/CKO mice, disease model mice
liveKO 190565 - Order
Apoe-KO/hSIRPA/hCD47
Xenograft-ApplicableKO/CKO mice, Target humanized mice
embryo cryopreservationXA 241005 - Order
Apoe-KO/hANGPTL3
Xenograft-ApplicableKO/CKO mice, Target humanized mice
liveXA 242593 - Order
Apoe-KO/Nos3-KO
Xenograft-ApplicableKO/CKO mice
liveXA 242509 - Order
Apoe-KO/hAPOC3
Xenograft-ApplicableKO/CKO mice, Target humanized mice
liveXA 242592 - Order
Apoe-KO/hPCSK9
Xenograft-ApplicableKO/CKO mice, Target humanized mice
liveXA 250813 - Order
Apoe-KO/Lyz2-Cre
Xenograft-ApplicableKO/CKO mice,Cre/Dre Toolbox of Mice
liveXA 241110
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Apoe (APOE) from ITL supported projects.
- Loss of SPRR3 in ApoE-/- mice leads to atheroma vulnerability through Akt dependent and independent effects in VSMCsLietman CD, Segedy AK, Li B, Fazio S, Atkinson JB, Linton MF, Young PP. (2017). PLoS One 12(9): e0184620
- NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3Hamblet CE, Makowski SL, Tritapoe JM, Pomerantz JL. (2016). J Immunol 196(6): 2614-26
- Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice.Zack M, Boyanovsky BB, Shridas P, Bailey W, Forrest K, Howatt DA, Gelb MH, de Beer FC, Daugherty A, Webb NR. (2011). Atherosclerosis 214: 58-64
Looking for a Apoe mouse model?
We have 8 Apoe models in stock — including Conditional Knockout, Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model8
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Apoe Mouse Model Types
A Apoe knockout mouse has the Apoe gene permanently inactivated, enabling loss of function studies. A Apoe conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Apoe, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Apoe organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Apoe.