Conventional / global / constitutive KO
●2 Models Available
Asxl1 Conditional Knockout, Knockout mouse models
Browse 2 Asxl1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Asxl1 conditional knockout mouse, Asxl1 knockout mouse. Contact us for availability and fast turnaround.
Why model Asxl1
Additional sex combs like 1, encoded by Asxl1 and orthologous to human ASXL1, scaffolds the polycomb repressive deubiquitinase complex by binding BAP1 through its ASXM region and stimulating removal of H2AK119 ubiquitin, while its PHD finger and HARE-HTH module direct chromatin engagement. Myeloid disease alleles cluster as frameshift and nonsense events in the final exon, producing a truncated protein that escapes degradation and behaves as a gain of function, enhancing BAP1 catalysis, depleting H3K27 trimethylation, and derepressing posterior HOXA genes in myelodysplastic syndrome, chronic myelomonocytic leukemia, and secondary AML. Design follows that distinction: a conditional null reports haploinsufficiency and steady-state hematopoiesis, whereas a knockin encoding the truncated mutant recapitulates clonal expansion and transformation that nulls miss entirely. Asxl2 and Asxl3 provide partial buffering in some tissues, so compound genetics may be warranted. Pair inducible Mx1-Cre or Vav-Cre with transplantation readouts when scoring stem cell self-renewal.
What Asxl1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Asxl1 (ASXL1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Asxl1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Asxl1 allele types
Knockout, conditional, knockin, humanized, and related paths for Asxl1 (human ASXL1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Asxl1 catalog models
2 Asxl1 lines with QC documentation and technical support. Asxl1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Asxl1 (ASXL1) from ITL supported projects.
- Dual ASXL1 and CSF3R mutations drive myeloid-biased stem cell expansion and enhance neutrophil differentiationDarmusey L, Bagley AJ, Nguyen TT, Carlson HL, Blaylock H, Shrestha SB, Pang A, Tauchmann S, Taylor SC, Foley AC, Niño KE, Pietras EM, Braun TP, Maxson JE. (2025). Blood Adv. 7(9): 1593-1607.
Looking for a Asxl1 mouse model?
We have 2 Asxl1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Asxl1 Mouse Model Types
A Asxl1 knockout mouse has the Asxl1 gene permanently inactivated, enabling loss of function studies. A Asxl1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Asxl1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Asxl1 organized by modification type. Each URL is indexable and matches common search patterns.