Conventional / global / constitutive KO
●1 Model Available
Atm Conditional Knockout mouse model
Browse 1 Atm mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Atm
Atm, the mouse ortholog of human ATM, encodes a PIKK family kinase held as an inactive dimer until the MRE11, RAD50 and NBS1 complex loads it at double strand breaks, where monomerization, autophosphorylation and acetylation by TIP60 activate phosphorylation of SQ and TQ motifs in KAP1, H2AX, CHK2 T68, p53 S15 and SMC1. This output enforces the G1/S and intra-S checkpoints, promotes heterochromatic break resection and couples oxidative stress to redox signaling. Null mice are viable but display thymic lymphoma, infertility, radiosensitivity and cerebellar signaling defects that only partially phenocopy ataxia telangiectasia, whereas kinase-dead knockin alleles are embryonic lethal because catalytically inert protein poisons break ends, a distinction that must inform allele choice. Conditional nulls are the right tool for tissue-restricted radiosensitization and synthetic lethality studies with ATR or PARP inhibitors, while patient-derived missense knockins address variant reclassification. Pair the allele with a Cre driver active in the lineage where checkpoint failure is being scored.
What Atm mouse models are available?
ingenious targeting laboratory offers 1 distinct Atm (ATM) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Atm model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Atm allele types
Knockout, conditional, knockin, humanized, and related paths for Atm (human ATM). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Atm catalog models
1 Atm line with QC documentation and technical support. Atm floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Atm-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 200047
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Atm (ATM) from ITL supported projects.
- LiCl treatment leads to long-term restoration of spine maturation and synaptogenesis in adult Tbr1 mutants.Darbandi S, Nelson A, Pai E, Bender K, Rubenstein J. (2022). J Neurodev Disord 14(1): 11
- AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia.Tirado-Gonzalez I, Descot A, Soetopo D, Nevmerzhitskaya A, Schäffer A, Kur IM, Czlonka E, Wachtel C, Tsoukala I, Müller L, Schäfer AL, Weitmann M, Dinse P, Alberto E, Buck MC, Landry JJ, Baying B, Slotta-Huspenina J, Roesler J, Harter PN, Kubasch AS, Meinel J, Elwakeel E, Strack E, Quang CT, Abdel-Wahab O, Schmitz M, Weigert A, Schmid T, Platzbecker U, Benes V, Ghysdael J, Bonig H, Götze KS, Rothlin CV, Ghosh S, Medyouf H. (2021). Cancer Discov 11(11): 2924-2943
Looking for a Atm mouse model?
We have 1 Atm model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
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Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Atm Mouse Model Types
A Atm conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Atm, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Atm organized by modification type. Each URL is indexable and matches common search patterns.