Conventional / global / constitutive KO
●2 Models Available
Bid Conditional Knockout, Knockout mouse models
Browse 2 Bid mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Bid conditional knockout mouse, Bid knockout mouse. Request a quote within 24 hours.
Why model Bid
Bid, ortholog of human BID, encodes the BH3-only protein that couples receptor-initiated to mitochondrial apoptosis. Full-length BID is a compact eight-helix protein held inactive until caspase-8, activated within the FAS or TNFR1 death-inducing complex, cleaves it at Asp59 to yield tBID, which becomes N-myristoylated, targets cardiolipin-rich mitochondrial membranes, and directly activates BAK and BAX; granzyme B, calpains, and cathepsins cut BID at nearby sites, extending the same logic to cytotoxic lymphocyte killing and lysosomal damage. BID is also an ATM substrate implicated in the S-phase checkpoint. Nulls are viable, resist FAS-driven hepatocyte apoptosis, and eventually develop myeloid expansion, but the extrinsic-to-intrinsic bridge is partly covered by Bcl2l11 and Bbc3, so compound genetics is often required. A non-cleavable Asp59 knockin is the sharpest tool for isolating caspase-8-dependent amplification, whereas conditional nulls with hepatocyte or myeloid Cre address tissue-specific death sensitivity.
What Bid mouse models are available?
ingenious targeting laboratory offers 2 distinct Bid (BID) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Bid model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Bid allele types
Knockout, conditional, knockin, humanized, and related paths for Bid (human BID). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Bid (BID) from ITL supported projects.
- Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxietyLee B, Kwon JT, Jeong Y, Caris H, Oh D, Feng M, Davila Mejia I, Zhang X, Ishikawa T, Watson BR, Moffitt JR, Chung K, Huh JR, Choi GB. (2025). Cell 8(188): 2190-2202.e15.
- Bidirectional and context-dependent changes in theta and gamma oscillatory brain activity in noradrenergic cell-specific Hypocretin/Orexin receptor 1-KO miceLi S, Franken P, Vassalli A. (2018). Sci Rep 8(1): 15474
- Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndromeNugent AA, Park JG, Wei Y, Tenney AP, Gilette NM, DeLisle MM, Chan WM, Cheng L, Engle EC. (2017). J Clin Invest 127(5): 1664-1682
- Nmp4/CIZ suppresses parathyroid hormone-induced increases in trabecular bone.Robling AG, Childress P, Yu J, Cotte J, Heller A, Philip BK, Bidwell JP. (2009). J Cell Physiol219: 734-743
Looking for a Bid mouse model?
We have 2 Bid models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Bid Mouse Model Types
A Bid knockout mouse has the Bid gene permanently inactivated, enabling loss of function studies. A Bid conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Bid, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Bid organized by modification type. Each URL is indexable and matches common search patterns.