Bmp7 Knockout mouse models
Bmp7, mouse ortholog of human BMP7 and long known as osteogenic protein 1, encodes a ligand acting through ALK2 and ALK3 with BMPR2 and ACVR2A to phosphorylate SMAD1, SMAD5, and SMAD8, and it is indispensable for metanephric mesenchyme survival, nephron progenitor maintenance, lens and retina induction, and eye and skeletal patterning, while also promoting brown adipocyte commitment through PRDM16 and UCP1. Constitutive nulls die within the first day after birth from renal dysplasia with anophthalmia or microphthalmia, so any adult fibrosis, kidney injury, or thermogenesis study requires conditional floxed alleles paired with drivers such as Six2-Cre, Pax8-Cre, or Adipoq-Cre. Its antifibrotic counterbalance against TGF-beta and SMAD3 makes ligand delivery and receptor-selective agonist testing a common goal, which favors epitope-matched humanization. Overlap with BMP5 and BMP6 in bone and kidney means single-locus deletion can understate the pathway requirement, so compound alleles should be considered when scoring interstitial fibrosis or tubular repair endpoints.
A conventional Bmp7 knockout removes gene function in all cells that inherit the allele. It is a proven first pass for target validation when redundancy is low.
What Bmp7 Knockout mouse models are available?
ingenious targeting laboratory offers 2 distinct Bmp7 knockout catalog mouse models. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Bmp7 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Bmp7 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Bmp7 Knockout mouse models are available?
When Bmp7 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Bmp7 knockout embryonic lethal in mice?
It depends on background and allele design. Some Bmp7 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Bmp7 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Bmp7?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.