Conventional / global / constitutive KO
●3 Models Available
Bmp7 Conditional Knockout, Knockout mouse models
Browse 3 Bmp7 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Bmp7 conditional knockout mouse, Bmp7 knockout mouse. Request a quote within 24 hours.
Why model Bmp7
Bmp7, mouse ortholog of human BMP7 and long known as osteogenic protein 1, encodes a ligand acting through ALK2 and ALK3 with BMPR2 and ACVR2A to phosphorylate SMAD1, SMAD5, and SMAD8, and it is indispensable for metanephric mesenchyme survival, nephron progenitor maintenance, lens and retina induction, and eye and skeletal patterning, while also promoting brown adipocyte commitment through PRDM16 and UCP1. Constitutive nulls die within the first day after birth from renal dysplasia with anophthalmia or microphthalmia, so any adult fibrosis, kidney injury, or thermogenesis study requires conditional floxed alleles paired with drivers such as Six2-Cre, Pax8-Cre, or Adipoq-Cre. Its antifibrotic counterbalance against TGF-beta and SMAD3 makes ligand delivery and receptor-selective agonist testing a common goal, which favors epitope-matched humanization. Overlap with BMP5 and BMP6 in bone and kidney means single-locus deletion can understate the pathway requirement, so compound alleles should be considered when scoring interstitial fibrosis or tubular repair endpoints.
What Bmp7 mouse models are available?
ingenious targeting laboratory offers 3 distinct Bmp7 (BMP7) catalog mouse models in the BMP/GDF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Bmp7 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Bmp7 allele types
Knockout, conditional, knockin, humanized, and related paths for Bmp7 (human BMP7). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Bmp7 catalog models
3 Bmp7 lines with QC documentation and technical support. Bmp7 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Bmp7 mouse model?
We have 3 Bmp7 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Bmp7 Mouse Model Types
A Bmp7 knockout mouse has the Bmp7 gene permanently inactivated, enabling loss of function studies. A Bmp7 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Bmp7, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Bmp7 organized by modification type. Each URL is indexable and matches common search patterns.