Conventional / global / constitutive KO
●3 Models Available
READY TO SHIP!
LIVE · EMBRYO
Braf Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Braf mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Braf conditional knockout mouse, Braf knockin mouse, Braf knockout mouse. Request a quote within 24 hours.
Why model Braf
Braf, the mouse ortholog of human BRAF, encodes the RAF family serine/threonine kinase that couples RAS-GTP to MEK1 and MEK2 through an N-terminal RAS binding domain and cysteine rich domain, an autoinhibitory 14-3-3 clamped conformation, and an obligate side-to-side kinase dimer interface. The V600E substitution within the activation segment mimics phosphorylation and signals as a RAS-independent monomer, whereas class II and class III alleles retain dimer or RAS dependence, a distinction that fully determines response to vemurafenib class inhibitors and explains paradoxical MAPK activation. Kinase-impaired germline variants instead drive cardiofaciocutaneous syndrome through altered dimer allostery. Constitutive null is embryonic lethal from vascular and placental failure, so conditional Lox-Stop-Lox V600E knockins driven by lineage-restricted Cre remain the standard for melanoma, thyroid, lung and colon models. Araf and Raf1 dimerize with BRAF and mediate resistance, so consider compound alleles. Match allele class to the inhibitor question, since monomer and dimer alleles predict opposite pharmacology.
What Braf mouse models are available?
ingenious targeting laboratory offers 3 distinct Braf (BRAF) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Braf model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Braf allele types
Knockout, conditional, knockin, humanized, and related paths for Braf (human BRAF). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Braf catalog models
3 Braf lines with QC documentation and technical support. Braf floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Braf-Flox
CKOCKO, Disease Model
These mice carry loxP sites flanking exon 5 of Braf gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Braf gene.
Embryo CryopreservedCKO 200073 - Order
Braf-Flox-V600E
KIPoint Mutation, Disease Model
These mice carry a conditional p.V600E mutation of Braf gene.
LiveKI 190053 - Order
Braf-KO
KOKO, Disease Model
Exon 5 of Braf gene was deleted to generate Braf knockout mice.
F0 Embryo CryopreservedKO 205008
Looking for a Braf mouse model?
We have 3 Braf models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Braf Mouse Model Types
A Braf knockout mouse has the Braf gene permanently inactivated, enabling loss of function studies. A Braf conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Braf, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Braf knockin models carry a precisely inserted sequence at the Braf locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Braf organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Braf line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.