Conventional / global / constitutive KO
●2 Models Available
C3ar1 Conditional Knockout, Knockin mouse models
Browse 2 C3ar1 mouse models including conditional knockout, knockin variants — in stock and ready to ship from ingenious targeting laboratory. Available as C3ar1 conditional knockout mouse, C3ar1 knockin mouse. Request a quote within 24 hours.
Why model C3ar1
The mouse C3ar1 locus encodes C3aR, ortholog of human C3AR1 and a class A rhodopsin-like G protein coupled receptor with an unusually large second extracellular loop that binds the carboxy-terminal arginine of the C3a anaphylatoxin. Signaling proceeds mainly through Galphai to inhibit adenylate cyclase and through Gbetagamma to PI3Kgamma and phospholipase Cbeta, mobilizing calcium and driving chemotaxis, degranulation, and inflammasome priming in mast cells, neutrophils, monocytes, and microglia, with additional roles in adipocyte and neural progenitor biology. Loss of C3aR protects in models of asthma, ischemia reperfusion injury, and complement-driven neuroinflammation while sparing opsonization, which makes it attractive for separating anaphylatoxin signaling from C3b effector function. Because C5ar1 responds to a related ligand and overlaps in myeloid distribution, single-receptor deletion can be buffered and compound C3ar1 C5ar1 alleles are frequently required. Conditional flox designs with myeloid or microglial Cre suit cell-of-action questions; humanization suits antagonist pharmacology.
What C3ar1 mouse models are available?
ingenious targeting laboratory offers 2 distinct C3ar1 (C3AR1) catalog mouse models, featuring conditional knockout and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
C3ar1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
C3ar1 allele types
Knockout, conditional, knockin, humanized, and related paths for C3ar1 (human C3AR1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available C3ar1 catalog models
2 C3ar1 lines with QC documentation and technical support. C3ar1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a C3ar1 mouse model?
We have 2 C3ar1 models in stock — including Conditional Knockout, Knockin types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About C3ar1 Mouse Model Types
A C3ar1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of C3ar1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. C3ar1 knockin models carry a precisely inserted sequence at the C3ar1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for C3ar1 organized by modification type. Each URL is indexable and matches common search patterns.