Conventional / global / constitutive KO
●2 Models Available
C9orf72 Conditional Knockout, Knockout mouse models
Browse 2 C9orf72 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as C9orf72 conditional knockout mouse, C9orf72 knockout mouse. Contact us for availability and fast turnaround.
Why model C9orf72
Faithful ALS and frontotemporal dementia modeling begins at C9orf72 (historically annotated 3110043O21Rik), the mouse ortholog of human C9ORF72, which encodes a DENN-domain guanine nucleotide exchange factor that partners stoichiometrically with SMCR8 and WDR41 to govern RAB GTPase cycling, ULK1-dependent autophagy initiation, and lysosomal trafficking. Disease arises from a GGGGCC hexanucleotide repeat expansion in intron 1 acting through three intertwined routes: transcriptional silencing and haploinsufficiency, sequestration of RNA-binding proteins into sense and antisense foci, and repeat-associated non-AUG translation into dipeptide repeat species including poly(GA), poly(GR), and poly(PR). Allele choice therefore encodes the hypothesis. Germline or conditional nulls interrogate loss of function, which in mice yields myeloid and microglial lysosomal defects plus autoimmunity rather than frank motor neuron death, repeat-expansion knockin or BAC alleles test gain of function, and humanized locus replacement enables antisense oligonucleotide and RNA-targeting campaigns. Match allele class to endpoint, pairing neuronal or myeloid Cre drivers with cell-type-restricted questions.
What C9orf72 mouse models are available?
ingenious targeting laboratory offers 2 distinct C9orf72 (C9orf72) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
C9orf72 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
C9orf72 allele types
Knockout, conditional, knockin, humanized, and related paths for C9orf72 (human C9orf72). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available C9orf72 catalog models
2 C9orf72 lines with QC documentation and technical support. C9orf72 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving C9orf72 from ITL supported projects.
- A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypesVerdone BM, Cicardi ME, Wen X, Sriramoji S, Russell K, Markandaiah SS, Jensen BK, Krishnamurthy K, Haeusler AR, Pasinelli P, Trotti D. (2022). Sci Rep 12(1): 5644
Looking for a C9orf72 mouse model?
We have 2 C9orf72 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About C9orf72 Mouse Model Types
A C9orf72 knockout mouse has the C9orf72 gene permanently inactivated, enabling loss of function studies. A C9orf72 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of C9orf72, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for C9orf72 organized by modification type. Each URL is indexable and matches common search patterns.