Conventional / global / constitutive KO
●2 Models Available
Casp8 Conditional Knockout, Knockout mouse models
Browse 2 Casp8 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Casp8 conditional knockout mouse, Casp8 knockout mouse. Request a quote within 24 hours.
Why model Casp8
As the apical death receptor caspase, mouse Casp8 is the ortholog of human CASP8 and carries tandem death effector domains that dock onto FADD within FAS, TRAIL receptor, or TNFR1 complex II, where dimerization and cleavage at Asp387 yield an active protease that processes BID and caspases 3 and 7. Equally important is its non-apoptotic role: caspase-8 cleaves RIPK1 and CYLD to restrain RIPK3 and MLKL dependent necroptosis, and it participates in FADD dependent inflammasome regulation. Germline deletion is embryonic lethal around E10.5 with yolk sac vascular failure, and that lethality is rescued by concurrent Ripk3 or Mlkl loss, the standard genetic proof that unrestrained necroptosis rather than lost apoptosis kills the embryo. Conditional flox alleles with epithelial or myeloid Cre are therefore mandatory for adult work, catalytically inactive C362A knockins isolate scaffolding, and human CASP8 knockins support study of patient variants causing lymphoproliferation and immunodeficiency.
What Casp8 mouse models are available?
ingenious targeting laboratory offers 2 distinct Casp8 (CASP8) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Casp8 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Casp8 allele types
Knockout, conditional, knockin, humanized, and related paths for Casp8 (human CASP8). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Casp8 catalog models
2 Casp8 lines with QC documentation and technical support. Casp8 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Casp8 mouse model?
We have 2 Casp8 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Casp8 Mouse Model Types
A Casp8 knockout mouse has the Casp8 gene permanently inactivated, enabling loss of function studies. A Casp8 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Casp8, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Casp8 organized by modification type. Each URL is indexable and matches common search patterns.