Conventional / global / constitutive KO
●2 Models Available
Cbfb Conditional Knockout, Knockout mouse models
Browse 2 Cbfb mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Cbfb conditional knockout mouse, Cbfb knockout mouse. Contact us for availability and fast turnaround.
Why model Cbfb
Cbfb, ortholog of human CBFB, encodes core binding factor beta, a non-DNA-binding subunit that heterodimerizes with the Runt domain of RUNX1, RUNX2, or RUNX3, allosterically increasing DNA affinity and protecting those factors from ubiquitin-mediated turnover. Loss of the heterodimer collapses definitive hematopoietic emergence from hemogenic endothelium, and homozygous deletion is embryonic lethal near E12.5 with central nervous system hemorrhage, so viable analysis requires conditional alleles or knockin rescue strategies. In leukemia the dominant lesion is the inversion 16 CBFB-MYH11 fusion, whose smooth muscle myosin tail sequesters RUNX1 into transcriptionally inert complexes, a dominant-negative mechanism no simple null reproduces. Model design therefore forks cleanly between conditional deletion for dosage and lineage specification questions and a Cre-inducible fusion knockin for core binding factor leukemia. Because all three RUNX paralogs share this beta subunit, Cbfb loss removes their activities simultaneously, so interpret compound phenotypes with that breadth in mind.
What Cbfb mouse models are available?
ingenious targeting laboratory offers 2 distinct Cbfb (CBFB) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cbfb model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cbfb allele types
Knockout, conditional, knockin, humanized, and related paths for Cbfb (human CBFB). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cbfb catalog models
2 Cbfb lines with QC documentation and technical support. Cbfb floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Cbfb mouse model?
We have 2 Cbfb models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cbfb Mouse Model Types
A Cbfb knockout mouse has the Cbfb gene permanently inactivated, enabling loss of function studies. A Cbfb conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cbfb, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Cbfb organized by modification type. Each URL is indexable and matches common search patterns.