Conventional / global / constitutive KO
●3 Models Available
Cd86 Conditional Knockout, Knockout mouse models
Browse 3 Cd86 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Cd86 conditional knockout mouse, Cd86 knockout mouse. Contact us for availability and fast turnaround.
Why model Cd86
Mouse Cd86 encodes B7-2, ortholog of human CD86, and is the costimulatory ligand dominating early T cell priming because it sits constitutively at low levels on resting antigen presenting cells and is rapidly upregulated after TLR or CD40 signaling, well before CD80 accumulates. Its IgV domain engages CD28 as a monomer with lower affinity but faster association than CD80, and it is likewise a preferred target for CTLA4 mediated transendocytosis, tying it directly to peripheral tolerance. CD86 also signals reciprocally into the presenting cell, influencing IL-6 production and immunoglobulin class switching in B cells. Because Cd80 provides substantial functional overlap, single nulls show only partial defects in germinal center formation and Th2 responses, and compound Cd80 Cd86 alleles are needed for clean loss of CD28 costimulation. Conditional flox designs with Cd19-Cre or Itgax-Cre localize the relevant presenter, while humanized knockins support CTLA4-Ig and anti-CD86 pharmacology.
What Cd86 mouse models are available?
ingenious targeting laboratory offers 3 distinct Cd86 (CD86) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cd86 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cd86 allele types
Knockout, conditional, knockin, humanized, and related paths for Cd86 (human CD86). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cd86 catalog models
3 Cd86 lines with QC documentation and technical support. Cd86 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Cd86 mouse model?
We have 3 Cd86 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cd86 Mouse Model Types
A Cd86 knockout mouse has the Cd86 gene permanently inactivated, enabling loss of function studies. A Cd86 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cd86, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Cd86 organized by modification type. Each URL is indexable and matches common search patterns.