Conventional / global / constitutive KO
●4 Models Available
READY TO SHIP!
SPERM · EMBRYO · IN PRODUCTION
Cd86 Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Cd86 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Cd86 conditional knockout mouse, Cd86 knockin mouse, Cd86 knockout mouse. Request a quote within 24 hours.
Why model Cd86
Mouse Cd86 encodes B7-2, ortholog of human CD86, and is the costimulatory ligand dominating early T cell priming because it sits constitutively at low levels on resting antigen presenting cells and is rapidly upregulated after TLR or CD40 signaling, well before CD80 accumulates. Its IgV domain engages CD28 as a monomer with lower affinity but faster association than CD80, and it is likewise a preferred target for CTLA4 mediated transendocytosis, tying it directly to peripheral tolerance. CD86 also signals reciprocally into the presenting cell, influencing IL-6 production and immunoglobulin class switching in B cells. Because Cd80 provides substantial functional overlap, single nulls show only partial defects in germinal center formation and Th2 responses, and compound Cd80 Cd86 alleles are needed for clean loss of CD28 costimulation. Conditional flox designs with Cd19-Cre or Itgax-Cre localize the relevant presenter, while humanized knockins support CTLA4-Ig and anti-CD86 pharmacology.
What Cd86 mouse models are available?
ingenious targeting laboratory offers 4 distinct Cd86 (CD86) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cd86 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cd86 allele types
Knockout, conditional, knockin, humanized, and related paths for Cd86 (human CD86). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cd86 catalog models
4 Cd86 lines with QC documentation and technical support. Cd86 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Cd86-Flox
CKOCKO
These strains carry loxP sites flanking exon 2 of Cd86 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Cd86 gene.
Sperm CryopreservedCKO 234628 - Order
Cd86-2A-CreERT2
KICre/Dre Toolbox
The 2A-CreERT2-WPRE-pA expression cassette was knocked into the Cd86 gene stop codon site.
In production — inquireKI 260889 - Order
Cd86-KO(2)
KOKO
The exon 2 of Cd86 gene was deleted to generate Cd86 knockout mouse.
Sperm CryopreservedKO 251299 - Order
Cd86-KO
KOKO
The Cd86 knockout mouse model was obtained by knocking out the exon 3-4 region of mouse Cd86 gene.
Embryo CryopreservedKO 18041
Looking for a Cd86 mouse model?
We have 4 Cd86 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cd86 Mouse Model Types
A Cd86 knockout mouse has the Cd86 gene permanently inactivated, enabling loss of function studies. A Cd86 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cd86, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Cd86 knockin models carry a precisely inserted sequence at the Cd86 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Cd86 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Cd86 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.