Conventional / global / constitutive KO
●2 Models Available
Cer1 Conditional Knockout, Knockout mouse models
Browse 2 Cer1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Cer1 conditional knockout mouse, Cer1 knockout mouse. Contact us for availability and fast turnaround.
Why model Cer1
Cer1, mouse ortholog of human CER1, encodes Cerberus 1, a secreted cysteine-knot DAN family antagonist expressed in anterior visceral endoderm and anterior primitive streak that binds and sequesters Nodal, BMP4, and in some contexts Wnt ligands, sculpting the anterior signaling shield that permits head formation and restricts posteriorizing signals. Its Nodal-binding activity also contributes to left-right asymmetry and to the periodicity of Nodal expression during somite and node development, and human variants have been reported in laterality and cardiac malformation cohorts. Mouse nulls are viable and grossly normal, an instructive negative result attributable to overlapping antagonism from Lefty1, Lefty2, Dand5, Nog, and Chrd, so compound genetics rather than a single knockout is required to expose anterior patterning failure. Given viability, allele choice should favor either compound antagonist deletion for developmental endpoints or reporter and conditional alleles for lineage tracing of anterior endoderm. Humanization is warranted only when assaying human CER1 protein directly in differentiation or organoid readouts.
What Cer1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Cer1 (CER1) catalog mouse models in the Antagonist/modulator family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cer1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cer1 allele types
Knockout, conditional, knockin, humanized, and related paths for Cer1 (human CER1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cer1 catalog models
2 Cer1 lines with QC documentation and technical support. Cer1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Cer1 mouse model?
We have 2 Cer1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cer1 Mouse Model Types
A Cer1 knockout mouse has the Cer1 gene permanently inactivated, enabling loss of function studies. A Cer1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cer1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Cer1 organized by modification type. Each URL is indexable and matches common search patterns.