Conventional / global / constitutive KO
●4 Models Available
READY TO SHIP!
SPERM
Cfd Conditional Knockout, Humanized, Knockout mouse models
Browse 4 Cfd mouse models including conditional knockout, humanized, knockout variants from ingenious targeting laboratory. Available as Cfd conditional knockout mouse, Cfd humanized mouse, Cfd knockout mouse. Contact us for availability and fast turnaround.
Why model Cfd
Complement factor D, also called adipsin, is encoded by mouse Cfd, ortholog of human CFD, and constitutes the rate-limiting protease of the alternative pathway. Factor D is unique among complement proteases in circulating as a mature enzyme rather than a zymogen, held in a self-inhibited conformation by a distorted active site and a blocking self-inhibitory loop that is relieved only upon docking to the exosite presented by factor B once factor B has engaged C3b, an elegant substrate-induced activation that prevents fluid phase proteolysis. It is secreted largely by adipocytes, linking metabolic tissue to complement amplification and insulin secretion biology. Human deficiency causes recurrent Neisseria infection, and mouse nulls lack alternative pathway activity while retaining classical function, with no paralog to compensate. Choose the null or an adipocyte-conditional allele to test tissue source and metabolic crosstalk, and humanized knockins when danicopan class molecules exploiting the self-inhibited pocket are the endpoint.
What Cfd mouse models are available?
ingenious targeting laboratory offers 4 distinct Cfd (CFD) catalog mouse models, featuring conditional knockout, standard knockout, and humanized. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cfd model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cfd allele types
Knockout, conditional, knockin, humanized, and related paths for Cfd (human CFD). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cfd catalog models
4 Cfd lines with QC documentation and technical support. Cfd floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout. Cfd humanized models carry the human gene sequence for translational research.
- Order
Cfd-Flox
CKOCKO
These mice carry loxP sites flanking exon 2-5 of Cfd gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Cfd gene.
Sperm CryopreservedCKO 251799 - Order
hCFD
HUTarget-Humanized, Disease Model
The endogenous mouse Cfd gene was replaced by human CFD gene.
Sperm CryopreservedHU 225045 - Order
Cfd-KO(2)
KOKO
The exon 2-5 of Cfd gene was deleted to generate Cfd knockout mouse.
Sperm CryopreservedKO 252936 - Order
Cfd-KO
KOKO
Exon 2-3 of Cfd gene was deleted to generate Cfd knockout mice.
Sperm CryopreservedKO 200116
Looking for a Cfd mouse model?
We have 4 Cfd models available — including Conditional Knockout, Humanized, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cfd Mouse Model Types
A Cfd knockout mouse has the Cfd gene permanently inactivated, enabling loss of function studies. A Cfd conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cfd, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. A Cfd humanized mouse replaces the mouse Cfd gene with the human ortholog for translational research and drug development.
Modifications available
Jump to catalog backed pages for Cfd organized by modification type. Each URL is indexable and matches common search patterns.
Cfd mouse model FAQ
What Cfd Conditional Knockout mouse models are available?
When Cfd Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Cfd knockout embryonic lethal in mice?
It depends on background and allele design. Some Cfd germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Cfd animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Cfd?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ingenious targeting laboratory
Send the Cfd line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.