Conventional / global / constitutive KO
●4 Models Available
Cfd Conditional Knockout, Knockout, Xenograft-Applicable mouse models
Browse 4 Cfd mouse models including conditional knockout, knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Cfd conditional knockout mouse, Cfd knockout mouse, Cfd xenograft-applicable mouse. Request a quote within 24 hours.
Why model Cfd
Complement factor D, also called adipsin, is encoded by mouse Cfd, ortholog of human CFD, and constitutes the rate-limiting protease of the alternative pathway. Factor D is unique among complement proteases in circulating as a mature enzyme rather than a zymogen, held in a self-inhibited conformation by a distorted active site and a blocking self-inhibitory loop that is relieved only upon docking to the exosite presented by factor B once factor B has engaged C3b, an elegant substrate-induced activation that prevents fluid phase proteolysis. It is secreted largely by adipocytes, linking metabolic tissue to complement amplification and insulin secretion biology. Human deficiency causes recurrent Neisseria infection, and mouse nulls lack alternative pathway activity while retaining classical function, with no paralog to compensate. Choose the null or an adipocyte-conditional allele to test tissue source and metabolic crosstalk, and humanized knockins when danicopan class molecules exploiting the self-inhibited pocket are the endpoint.
What Cfd mouse models are available?
ingenious targeting laboratory offers 4 distinct Cfd (CFD) catalog mouse models, featuring conditional knockout, standard knockout, and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Cfd model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cfd allele types
Knockout, conditional, knockin, humanized, and related paths for Cfd (human CFD). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cfd catalog models
4 Cfd lines with QC documentation and technical support. Cfd floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Cfd mouse model?
We have 4 Cfd models in stock — including Conditional Knockout, Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cfd Mouse Model Types
A Cfd knockout mouse has the Cfd gene permanently inactivated, enabling loss of function studies. A Cfd conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cfd, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Cfd organized by modification type. Each URL is indexable and matches common search patterns.