Conventional / global / constitutive KO
●2 Models Available
Cntnap2 Conditional Knockout, Knockout mouse models
Browse 2 Cntnap2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Cntnap2 conditional knockout mouse, Cntnap2 knockout mouse. Contact us for availability and fast turnaround.
Why model Cntnap2
Cntnap2, ortholog of human CNTNAP2, encodes CASPR2, a neurexin superfamily single-pass adhesion molecule whose ectodomain combines discoidin, laminin G, EGF and fibrinogen-like modules and whose short cytoplasmic tail binds protein 4.1B; at myelinated axon juxtaparanodes it forms a ternary complex with TAG-1 (Contactin-2) to cluster Kv1.1 and Kv1.2 channels and prevent aberrant reexcitation, and it also functions at cortical synapses and in interneuron migration. Recessive truncating alleles cause cortical dysplasia focal epilepsy syndrome, common variants associate with language and autism phenotypes, and the CASPR2 ectodomain is a major autoantigen in limbic encephalitis and Morvan syndrome. Constitutive nulls are viable and reproduce interneuron loss, abnormal ultrasonic vocalization and repetitive behavior, giving a workable model, while a humanized ectodomain allele uniquely supports patient autoantibody and immunotherapy studies. Note the extreme locus size, over two megabases, which constrains full-locus humanization and favors targeted domain replacement with careful conditional exon design.
What Cntnap2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Cntnap2 (CNTNAP2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cntnap2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cntnap2 allele types
Knockout, conditional, knockin, humanized, and related paths for Cntnap2 (human CNTNAP2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cntnap2 catalog models
2 Cntnap2 lines with QC documentation and technical support. Cntnap2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Cntnap2 mouse model?
We have 2 Cntnap2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cntnap2 Mouse Model Types
A Cntnap2 knockout mouse has the Cntnap2 gene permanently inactivated, enabling loss of function studies. A Cntnap2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cntnap2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Cntnap2 organized by modification type. Each URL is indexable and matches common search patterns.