Cox6a1 Knockout mouse models
Charcot-Marie-Tooth disease provides the clearest disease logic for Cox6a1, the mouse ortholog of human COX6A1, which encodes the ubiquitously expressed isoform of cytochrome c oxidase subunit 6A, a transmembrane subunit contacting the MT-CO3 side of the enzyme and contributing to holoenzyme stability and dimer contacts. Biallelic loss of function variants in humans cause recessive intermediate Charcot-Marie-Tooth neuropathy type D with reduced complex IV activity, and reduced gene dosage in mouse has been used to model the peripheral nerve phenotype. Allele choice follows the endpoint: a conditional null defines tissue requirement and can be directed to Schwann cells or neurons, while hypomorphic or patient knockins reproduce partial deficiency and axonal pathology. The muscle restricted paralog Cox6a2 is co-expressed in heart and skeletal muscle and can blunt phenotypes there, so plan compound alleles for striated tissue. Use Dhh-Cre or Nes-Cre with nerve conduction studies, morphometry, and complex IV activity.
A conventional Cox6a1 knockout removes gene function in all cells that inherit the allele. It is a proven first pass for target validation when redundancy is low.
What Cox6a1 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Cox6a1 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Cox6a1-KO | Knockout | KO/CKO mice | embryo cryopreservation | KO 200935 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Cox6a1 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Cox6a1 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Cox6a1 Knockout mouse models are available?
When Cox6a1 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Cox6a1 knockout embryonic lethal in mice?
It depends on background and allele design. Some Cox6a1 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Cox6a1 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Cox6a1?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.