Conventional / global / constitutive KO
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SPERM
Crebbp Conditional Knockout mouse model
Browse 1 Crebbp mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Crebbp
CREB binding protein, encoded by Crebbp and orthologous to human CREBBP, is a KAT3 family lysine acetyltransferase that deposits H3K18 and H3K27 acetylation at enhancers and, through KIX, TAZ1, TAZ2, bromodomain, and nuclear coactivator binding modules, bridges sequence-specific factors including CREB, TP53, MYB, and IRF proteins to the basal machinery. Lymphoma alleles are dominated by HAT domain missense substitutions such as R1446C and by truncations that reduce enhancer acetylation at MHC class II and BCL6 target loci, while germline heterozygous loss produces Rubinstein-Taybi syndrome. Homozygous deletion is embryonic lethal with hematopoietic and neural tube defects, making conditional deletion the practical route, and catalytically dead knockins separate acetyltransferase output from scaffolding. The paralog Ep300 shares substrates and buffers partial loss, which is exactly why CREBBP mutant tumors show heightened EP300 dependency. Use heterozygous conditional loss for immune evasion endpoints and compound Crebbp with Ep300 alleles for synthetic lethality validation.
What Crebbp mouse models are available?
ingenious targeting laboratory offers 1 distinct Crebbp (CREBBP) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Crebbp model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Crebbp allele types
Knockout, conditional, knockin, humanized, and related paths for Crebbp (human CREBBP). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Crebbp catalog models
1 Crebbp line with QC documentation and technical support. Crebbp floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Crebbp-Flox
CKOCKO
These mice carry loxP sites flanking exon7-8 of Crebbp gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Crebbp gene.
Sperm CryopreservedCKO 190016
Looking for a Crebbp mouse model?
We have 1 Crebbp model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Crebbp Mouse Model Types
A Crebbp conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Crebbp, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Crebbp organized by modification type. Each URL is indexable and matches common search patterns.
Crebbp mouse model FAQ
What Crebbp Conditional Knockout mouse models are available?
When Crebbp Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Crebbp knockout embryonic lethal in mice?
It depends on background and allele design. Some Crebbp germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Crebbp animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Crebbp?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ingenious targeting laboratory
Send the Crebbp line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.