Conventional / global / constitutive KO
●4 Models Available
READY TO SHIP!
LIVE · SPERM
Ctnnb1 Conditional Knockout, Knockout mouse models
Browse 4 Ctnnb1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Ctnnb1 conditional knockout mouse, Ctnnb1 knockout mouse. Request a quote within 24 hours.
Why model Ctnnb1
To model Wnt signaling accurately, researchers must target Ctnnb1, the mouse ortholog of human CTNNB1, which encodes β-catenin, the central cytosolic pool and transcriptional effector of the canonical Wnt pathway. Upon pathway activation, β-catenin escapes destruction-complex phosphorylation, accumulates, and translocates to the nucleus to bind TCF/LEF factors, driving genes linked to stemness and oncogenesis. Consequently, model designs must explicitly separate absolute pathway collapse (via conditional null alleles) from hyperactivation (via exon 3 deletion or degron-evading mutations) or epitope-matched humanization for therapeutic antibody testing. Because homologous cadherin-associated or plakoglobin family members can functionally compensate for local loss, planning compound conditional genetics early prevents the discovery of masked phenotypes after a single-locus knockout. Ultimately, matching the specific Ctnnb1 allele class to your endpoint, whether assessing downstream signaling readouts, tumor latency in cooperation with partners like Apc, or drug response, is critical, as a trusted, validated Cre driver is just as vital as the flox design itself.
What Ctnnb1 mouse models are available?
ingenious targeting laboratory offers 4 distinct Ctnnb1 (beta catenin) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ctnnb1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ctnnb1 allele types
Knockout, conditional, knockin, humanized, and related paths for Ctnnb1 (human CTNNB1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ctnnb1 catalog models
4 Ctnnb1 lines with QC documentation and technical support. Ctnnb1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Ctnnb1-Flox
CKOCKO
These strains carry rox sites flanking exon 2-6 of Ctnnb1 gene. When crossed with a Dre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ctnnb1 gene.
Sperm CryopreservedCKO 242818 - Order
Ctnnb1-Flox
CKOCKO, Disease Model
These mice carry loxP sites flanking exon 2-6 of Ctnnb1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ctnnb1 gene.
LiveCKO 200154 - Order
Ctnnb1-KO(2)
KOKO
The exon 2-6 of Ctnnb1 gene was deleted to generate Ctnnb1 knockout mouse.
Sperm CryopreservedKO 250671 - Order
Ctnnb1-KO
KOKO
Exon 3-6 of Ctnnb1 gene was deleted to generate Ctnnb1 knockout mice.
Sperm CryopreservedKO 190634
Looking for a Ctnnb1 mouse model?
We have 4 Ctnnb1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ctnnb1 Mouse Model Types
A Ctnnb1 knockout mouse has the Ctnnb1 gene permanently inactivated, enabling loss of function studies. A Ctnnb1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ctnnb1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ctnnb1 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Ctnnb1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.