Conventional / global / constitutive KO
●5 Models Available
Ctnnb1 Conditional Knockout, Knockout, Xenograft-Applicable mouse models
Browse 5 Ctnnb1 mouse models including conditional knockout, knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Ctnnb1 conditional knockout mouse, Ctnnb1 knockout mouse, Ctnnb1 xenograft-applicable mouse. Request a quote within 24 hours.
Why model Ctnnb1
To model Wnt signaling accurately, researchers must target Ctnnb1, the mouse ortholog of human CTNNB1, which encodes β-catenin, the central cytosolic pool and transcriptional effector of the canonical Wnt pathway. Upon pathway activation, β-catenin escapes destruction-complex phosphorylation, accumulates, and translocates to the nucleus to bind TCF/LEF factors, driving genes linked to stemness and oncogenesis. Consequently, model designs must explicitly separate absolute pathway collapse (via conditional null alleles) from hyperactivation (via exon 3 deletion or degron-evading mutations) or epitope-matched humanization for therapeutic antibody testing. Because homologous cadherin-associated or plakoglobin family members can functionally compensate for local loss, planning compound conditional genetics early prevents the discovery of masked phenotypes after a single-locus knockout. Ultimately, matching the specific Ctnnb1 allele class to your endpoint, whether assessing downstream signaling readouts, tumor latency in cooperation with partners like Apc, or drug response, is critical, as a trusted, validated Cre driver is just as vital as the flox design itself.
What Ctnnb1 mouse models are available?
ingenious targeting laboratory offers 5 distinct Ctnnb1 (beta catenin) catalog mouse models, featuring conditional knockout, standard knockout, and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 5 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Ctnnb1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ctnnb1 allele types
Knockout, conditional, knockin, humanized, and related paths for Ctnnb1 (human CTNNB1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ctnnb1 catalog models
5 Ctnnb1 lines with QC documentation and technical support. Ctnnb1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Ctnnb1-Flox
Conditional KnockoutKO/CKO mice
liveCKO 242818 - Order
Ctnnb1-Flox
Conditional KnockoutKO/CKO mice, disease model mice
liveCKO 200154 - Order
Ctnnb1-KO(2)
KnockoutKO/CKO mice
sperm cryopreservationKO 250671 - Order
Ctnnb1-KO
KnockoutKO/CKO mice
sperm cryopreservationKO 190634 - Order
Ctnnb1-Flox/Alb-Cre-Tg(NMX)
Xenograft-ApplicableKO/CKO mice,Cre/Dre Toolbox of Mice, random transgenic mice
liveXA 251998
Looking for a Ctnnb1 mouse model?
We have 5 Ctnnb1 models in stock — including Conditional Knockout, Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model5
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ctnnb1 Mouse Model Types
A Ctnnb1 knockout mouse has the Ctnnb1 gene permanently inactivated, enabling loss of function studies. A Ctnnb1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ctnnb1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ctnnb1 organized by modification type. Each URL is indexable and matches common search patterns.