Conventional / global / constitutive KO
●2 Models Available
Cyp26a1 Conditional Knockout, Knockout mouse models
Browse 2 Cyp26a1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Cyp26a1 conditional knockout mouse, Cyp26a1 knockout mouse. Contact us for availability and fast turnaround.
Why model Cyp26a1
Cyp26a1, ortholog of human CYP26A1, encodes the principal retinoic acid catabolizing cytochrome P450, a microsomal enzyme that hydroxylates all-trans retinoic acid at carbon 4 and drives it toward oxo and polar metabolites, thereby carving retinoid-free zones adjacent to RALDH2-derived source domains and sharpening hindbrain, tailbud, and limb boundaries. The gene is itself a direct RAR target, forming a negative feedback loop that buffers retinoid excess, and its induction contributes to resistance against all-trans retinoic acid therapy in acute promyelocytic leukemia. Germline nulls die during gestation or shortly after birth with caudal truncation, spina bifida, and cervical vertebral transformations that phenocopy retinoid teratogenesis, so any postnatal or adult study requires conditional floxed alleles. Enzyme-dead knockins distinguish catalysis from expression, and humanized alleles are appropriate for testing CYP26 inhibitors such as talarozole. Because Cyp26b1 and Cyp26c1 clear retinoic acid in adjacent territories, compound conditionals are needed where domains abut, notably hindbrain rhombomeres.
What Cyp26a1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Cyp26a1 (CYP26A1) catalog mouse models in the Retinoic acid axis family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cyp26a1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cyp26a1 allele types
Knockout, conditional, knockin, humanized, and related paths for Cyp26a1 (human CYP26A1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cyp26a1 catalog models
2 Cyp26a1 lines with QC documentation and technical support. Cyp26a1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Cyp26a1 mouse model?
We have 2 Cyp26a1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cyp26a1 Mouse Model Types
A Cyp26a1 knockout mouse has the Cyp26a1 gene permanently inactivated, enabling loss of function studies. A Cyp26a1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cyp26a1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Cyp26a1 organized by modification type. Each URL is indexable and matches common search patterns.