Conventional / global / constitutive KO
●1 Model Available
Cyp26b1 Conditional Knockout mouse model
Browse 1 Cyp26b1 mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Cyp26b1
Encoding a second retinoic acid 4-hydroxylase, Cyp26b1 is the mouse ortholog of human CYP26B1 and shields specific tissues from retinoid exposure rather than shaping the trunk axis, most decisively in the fetal testis, where its expression in Sertoli and interstitial cells degrades retinoic acid to keep male germ cells from entering meiosis prematurely, and in skin, where it restrains epidermal retinoid tone. Germline deletion is lethal shortly after birth with a severe permeability barrier defect, limb and craniofacial abnormalities, and ectopic germ cell meiosis, while biallelic human variants cause craniosynostosis with radiohumeral fusion. That neonatal lethality makes conditional floxed alleles essential for adult skin, immune, and spermatogenic questions, and catalytically inactive knockins separate hydroxylase output from protein presence. Because Cyp26a1 and Cyp26c1 clear the same substrate in overlapping fields such as hindbrain, single-locus loss can be partially buffered. Match tissue-restricted Cre drivers, Krt14-Cre for barrier or Amh-Cre for Sertoli cells, to the specific retinoid threshold being tested.
What Cyp26b1 mouse models are available?
ingenious targeting laboratory offers 1 distinct Cyp26b1 (CYP26B1) catalog mouse model in the Retinoic acid axis family, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cyp26b1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cyp26b1 allele types
Knockout, conditional, knockin, humanized, and related paths for Cyp26b1 (human CYP26B1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cyp26b1 catalog models
1 Cyp26b1 line with QC documentation and technical support. Cyp26b1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Cyp26b1-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 220221
Looking for a Cyp26b1 mouse model?
We have 1 Cyp26b1 model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cyp26b1 Mouse Model Types
A Cyp26b1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cyp26b1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Cyp26b1 organized by modification type. Each URL is indexable and matches common search patterns.