Conventional / global / constitutive KO
●2 Models Available
Cyp26c1 Conditional Knockout, Knockout mouse models
Browse 2 Cyp26c1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Cyp26c1 conditional knockout mouse, Cyp26c1 knockout mouse. Contact us for availability and fast turnaround.
Why model Cyp26c1
Cyp26c1, mouse ortholog of human CYP26C1, encodes the third retinoic acid hydroxylase of the family, distinguished by its ability to act on both all-trans and 9-cis retinoic acid and by a sharply restricted expression pattern in rhombomeres 2 and 4, first branchial arch, and inner ear, where it refines local retinoid clearance beyond what the other isoforms supply. Human variants combined with CYP26B1 lesions have been reported in focal facial dermal dysplasia, consistent with an additive retinoid-clearance requirement. Single nulls are viable and essentially normal, which is the central design fact: informative genetics requires compound deletion with Cyp26a1, where double mutants show markedly enhanced hindbrain and rostral patterning defects that neither allele produces alone. Accordingly, invest in a floxed allele that can be combined sequentially rather than a plain knockout, and consider enzyme-dead knockins when substrate preference between all-trans and 9-cis isomers is the question. Reserve humanization for inhibitor selectivity profiling against defined craniofacial or otic endpoints.
What Cyp26c1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Cyp26c1 (CYP26C1) catalog mouse models in the Retinoic acid axis family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cyp26c1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cyp26c1 allele types
Knockout, conditional, knockin, humanized, and related paths for Cyp26c1 (human CYP26C1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cyp26c1 catalog models
2 Cyp26c1 lines with QC documentation and technical support. Cyp26c1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Cyp26c1 mouse model?
We have 2 Cyp26c1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cyp26c1 Mouse Model Types
A Cyp26c1 knockout mouse has the Cyp26c1 gene permanently inactivated, enabling loss of function studies. A Cyp26c1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cyp26c1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Cyp26c1 organized by modification type. Each URL is indexable and matches common search patterns.