Conventional / global / constitutive KO
●1 Model Available
Daxx Conditional Knockout mouse model
Browse 1 Daxx mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Daxx
Death domain associated protein, encoded by Daxx and orthologous to human DAXX, is a dedicated histone chaperone that captures the H3.3 to H4 dimer through variant-specific recognition of alanine 87, isoleucine 89, and glycine 90, then hands it to ATRX for deposition at telomeres, pericentromeric repeats, and endogenous retroviral elements. SUMO-interacting motifs additionally localize it to PML nuclear bodies, where it sequesters transcription factors and modulates apoptotic signaling. Inactivating mutations co-occur with ATRX loss in pancreatic neuroendocrine tumors and drive alternative lengthening of telomeres through defective heterochromatin maintenance and replication stress at repeats. Constitutive deletion causes embryonic lethality near E9.5 with widespread apoptosis, so conditional alleles paired with lineage or tamoxifen-inducible Cre are essential for adult tumor work. ATRX cannot substitute for chaperone activity, making compound analysis informative rather than redundant. Align allele class with telomere maintenance, retroelement derepression, or tumor latency as the intended readout.
What Daxx mouse models are available?
ingenious targeting laboratory offers 1 distinct Daxx (DAXX) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Daxx model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Daxx allele types
Knockout, conditional, knockin, humanized, and related paths for Daxx (human DAXX). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Daxx catalog models
1 Daxx line with QC documentation and technical support. Daxx floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Daxx-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 2100687
Looking for a Daxx mouse model?
We have 1 Daxx model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Daxx Mouse Model Types
A Daxx conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Daxx, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Daxx organized by modification type. Each URL is indexable and matches common search patterns.