Conventional / global / constitutive KO
●1 Model Available
Ep300 Conditional Knockout mouse model
Browse 1 Ep300 mouse model including conditional knockout variants — in stock and ready to ship from ingenious targeting laboratory. Request a quote within 24 hours.
Why model Ep300
Ep300 encodes p300, the mouse ortholog of human EP300 and the second KAT3 family acetyltransferase, which deposits H3K27 acetylation to mark active enhancers, requires autoacetylation of its activation loop for full catalysis, and uses TAZ1, TAZ2, KIX, and bromodomain modules to nucleate coactivator assemblies with HIF1A, TP53, MYB, and nuclear receptors. Cancer alleles include truncations and HAT domain missense mutations in bladder carcinoma, lymphoma, and colorectal tumors, and the paralog relationship is asymmetric enough that CREBBP mutant tumors become dependent on residual p300, an actionable synthetic lethality now targeted by catalytic and bromodomain inhibitors. Homozygous deletion causes embryonic lethality with cardiac and neural defects, so conditional alleles are mandatory for adult studies, and HAT-dead knockins separate enzymatic from scaffolding contributions. Because Crebbp compensates at many enhancers, single conditional deletion often yields muted transcriptional phenotypes, so plan compound genetics with Cre drivers matched to the tumor lineage.
What Ep300 mouse models are available?
ingenious targeting laboratory offers 1 distinct Ep300 (EP300) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ep300 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ep300 allele types
Knockout, conditional, knockin, humanized, and related paths for Ep300 (human EP300). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ep300 catalog models
1 Ep300 line with QC documentation and technical support. Ep300 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Ep300-Flox
Conditional KnockoutKO/CKO mice
liveCKO 190021
Looking for a Ep300 mouse model?
We have 1 Ep300 model in stock — including Conditional Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ep300 Mouse Model Types
A Ep300 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ep300, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ep300 organized by modification type. Each URL is indexable and matches common search patterns.