Conventional / global / constitutive KO
●2 Models Available
Epas1 Conditional Knockout, Knockout mouse models
Browse 2 Epas1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Epas1 conditional knockout mouse, Epas1 knockout mouse. Contact us for availability and fast turnaround.
Why model Epas1
Epas1, the mouse ortholog of human EPAS1, encodes HIF2 alpha, a bHLH-PAS transcription factor that dimerizes with ARNT and, in normoxia, is hydroxylated at prolines 405 and 531 by EGLN1 and related prolyl hydroxylases, creating the VHL recognition site for proteasomal destruction, while FIH hydroxylation of an asparagine blocks p300 recruitment. HIF2 alpha drives a target set biased toward erythropoietin, VEGFA and the endothelial and renal programs, distinct from the glycolytic bias of HIF1 alpha. Gain of function mutations at the hydroxylation sites cause erythrocytosis with paraganglioma and pheochromocytoma, and the druggable PAS-B cavity is the basis of belzutifan, so a knockin of a hydroxylation-resistant allele such as the human P531 variant is the appropriate tool for testing HIF2 alpha selective inhibitors. Null mice show strain-dependent embryonic and perinatal lethality from catecholamine and vascular defects, so conditional deletion is preferable. Hif1a occupies overlapping HREs, making double conditional alleles necessary for isoform assignment.
What Epas1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Epas1 (EPAS1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Epas1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Epas1 allele types
Knockout, conditional, knockin, humanized, and related paths for Epas1 (human EPAS1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Epas1 catalog models
2 Epas1 lines with QC documentation and technical support. Epas1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Epas1 mouse model?
We have 2 Epas1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Epas1 Mouse Model Types
A Epas1 knockout mouse has the Epas1 gene permanently inactivated, enabling loss of function studies. A Epas1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Epas1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Epas1 organized by modification type. Each URL is indexable and matches common search patterns.