Conventional / global / constitutive KO
●5 Models Available
READY TO SHIP!
SPERM · EMBRYO
Erbb4 Conditional Knockout, Knockin, Knockout mouse models
Browse 5 Erbb4 mouse models including conditional knockout, knockin, knockout variants from ingenious targeting laboratory. Available as Erbb4 conditional knockout mouse, Erbb4 knockin mouse, Erbb4 knockout mouse. Contact us for availability and fast turnaround.
Why model Erbb4
Erbb4, mouse ortholog of human ERBB4, encodes the only ERBB member that is both a fully active tyrosine kinase and a regulated intramembrane proteolysis substrate, binding neuregulins 1 through 4 and heparin binding EGF. Alternative splicing generates JM-a isoforms that contain a TACE and ADAM17 cleavage site permitting ectodomain shedding followed by gamma-secretase release of a soluble intracellular domain that translocates to the nucleus and partners with YAP, STAT5A and ETO2, versus JM-b isoforms that are not cleavable, and CYT-1 isoforms that carry a PI3K p85 binding site versus CYT-2 isoforms that do not. This isoform architecture means a conventional null conflates four biologically distinct receptors, so isoform-selective knockins are the correct design for neurodevelopmental, cardiac and mammary questions. Null mice die at midgestation from cardiac trabeculation failure and cranial ganglion defects, requiring conditional alleles. Erbb2 is the obligate heterodimer partner, so pair alleles when testing whether phenotypes reflect receptor loss or dimer loss.
What Erbb4 mouse models are available?
ingenious targeting laboratory offers 5 distinct Erbb4 (ERBB4) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 5 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Erbb4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Erbb4 allele types
Knockout, conditional, knockin, humanized, and related paths for Erbb4 (human ERBB4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Erbb4 catalog models
5 Erbb4 lines with QC documentation and technical support. Erbb4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Erbb4-Flox
CKOCKO, Disease Model
These mice carry loxP sites flanking exon2 of Erbb4 When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Erbb4 gene.
Sperm CryopreservedCKO 220295 - Order
Erbb4-I712M
KIPoint Mutation, Disease Model
These mice carry a I712M mutation of Erbb4 gene.
Embryo CryopreservedKI 200283 - Order
Erbb4-R1259W
KIPoint Mutation, Disease Model
These mice carry a R1259W mutation of Erbb4 gene.
Embryo CryopreservedKI 200282 - Order
Erbb4-R927Q
KIPoint Mutation, Disease Model
These mice carry a R927Q mutation of Erbb4 gene.
Embryo CryopreservedKI 200281 - Order
Erbb4-KO
KOKO, Disease Model
The exon2 of Erbb4 gene was deleted to generate Erbb4 knockout mouse.
Sperm CryopreservedKO 232939
Looking for a Erbb4 mouse model?
We have 5 Erbb4 models available — including Conditional Knockout, Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model5
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Erbb4 Mouse Model Types
A Erbb4 knockout mouse has the Erbb4 gene permanently inactivated, enabling loss of function studies. A Erbb4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Erbb4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Erbb4 knockin models carry a precisely inserted sequence at the Erbb4 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Erbb4 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Erbb4 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.