Conventional / global / constitutive KO
●5 Models Available
Erbb4 Conditional Knockout, Knockin, Knockout mouse models
Browse 5 Erbb4 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Erbb4 conditional knockout mouse, Erbb4 knockin mouse, Erbb4 knockout mouse. Request a quote within 24 hours.
Why model Erbb4
Erbb4, mouse ortholog of human ERBB4, encodes the only ERBB member that is both a fully active tyrosine kinase and a regulated intramembrane proteolysis substrate, binding neuregulins 1 through 4 and heparin binding EGF. Alternative splicing generates JM-a isoforms that contain a TACE and ADAM17 cleavage site permitting ectodomain shedding followed by gamma-secretase release of a soluble intracellular domain that translocates to the nucleus and partners with YAP, STAT5A and ETO2, versus JM-b isoforms that are not cleavable, and CYT-1 isoforms that carry a PI3K p85 binding site versus CYT-2 isoforms that do not. This isoform architecture means a conventional null conflates four biologically distinct receptors, so isoform-selective knockins are the correct design for neurodevelopmental, cardiac and mammary questions. Null mice die at midgestation from cardiac trabeculation failure and cranial ganglion defects, requiring conditional alleles. Erbb2 is the obligate heterodimer partner, so pair alleles when testing whether phenotypes reflect receptor loss or dimer loss.
What Erbb4 mouse models are available?
ingenious targeting laboratory offers 5 distinct Erbb4 (ERBB4) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 5 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Erbb4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Erbb4 allele types
Knockout, conditional, knockin, humanized, and related paths for Erbb4 (human ERBB4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Erbb4 catalog models
5 Erbb4 lines with QC documentation and technical support. Erbb4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Erbb4-Flox
Conditional KnockoutKO/CKO mice, disease model mice
liveCKO 220295 - Order
Erbb4-I712M
Knockinpoint mutantion mice, disease model mice
embryo cryopreservationKI 200283 - Order
Erbb4-R1259W
Knockinpoint mutantion mice, disease model mice
embryo cryopreservationKI 200282 - Order
Erbb4-R927Q
Knockinpoint mutantion mice, disease model mice
embryo cryopreservationKI 200281 - Order
Erbb4-KO
KnockoutKO/CKO mice, disease model mice
sperm cryopreservationKO 232939
Looking for a Erbb4 mouse model?
We have 5 Erbb4 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model5
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Erbb4 Mouse Model Types
A Erbb4 knockout mouse has the Erbb4 gene permanently inactivated, enabling loss of function studies. A Erbb4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Erbb4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Erbb4 knockin models carry a precisely inserted sequence at the Erbb4 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Erbb4 organized by modification type. Each URL is indexable and matches common search patterns.