Conventional / global / constitutive KO
●5 Models Available
Esr1 Conditional Knockout, Knockin, Knockout mouse models
Browse 5 Esr1 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Esr1 conditional knockout mouse, Esr1 knockin mouse, Esr1 knockout mouse. Request a quote within 24 hours.
Why model Esr1
Esr1, the mouse ortholog of human ESR1, encodes estrogen receptor alpha, a nuclear receptor with a ligand-independent AF-1 region, a zinc finger DNA binding domain that recognizes palindromic estrogen response elements as a homodimer, and a ligand binding domain whose helix 12 repositioning creates the AF-2 surface for NCOA coactivators, with additional membrane-initiated signaling from a palmitoylated pool. Acquired ligand binding domain mutations Y537S and D538G stabilize the agonist conformation and drive endocrine therapy resistance, whereas ESR1 fusions and amplification act by other routes, so a conditional knockin of Y537S is the right tool for resistance pharmacology and a floxed null answers lineage requirement in mammary epithelium, uterus, bone, hypothalamus and vasculature. Separation-of-function knockins that disable DNA binding or AF-2 distinguish genomic from nongenomic signaling. Null mice are viable but infertile with uterine hypoplasia, so constitutive alleles are usable, though Esr2 mediates distinct ovarian functions rather than compensating. Pair conditional alleles with a tissue-matched Cre.
What Esr1 mouse models are available?
ingenious targeting laboratory offers 5 distinct Esr1 (ESR1) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 5 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Esr1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Esr1 allele types
Knockout, conditional, knockin, humanized, and related paths for Esr1 (human ESR1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Esr1 catalog models
5 Esr1 lines with QC documentation and technical support. Esr1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Esr1-Flox(2)
Conditional KnockoutKO/CKO mice
liveCKO 200175 - Order
Esr1-2A-CreERT2
KnockinCre/Dre Toolbox of Mice
sperm cryopreservationKI 233481 - Order
Esr1-2A-Cre
KnockinCre/Dre Toolbox of Mice
liveKI 200164 - Order
Esr1-KO(3)
KnockoutKO/CKO mice
embryo cryopreservationKO 210243 - Order
Esr1-KO
KnockoutKO/CKO mice, disease model mice
liveKO 190631
Looking for a Esr1 mouse model?
We have 5 Esr1 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model5
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Esr1 Mouse Model Types
A Esr1 knockout mouse has the Esr1 gene permanently inactivated, enabling loss of function studies. A Esr1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Esr1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Esr1 knockin models carry a precisely inserted sequence at the Esr1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Esr1 organized by modification type. Each URL is indexable and matches common search patterns.