Conventional / global / constitutive KO
●1 Model Available
Ezh2 Conditional Knockout mouse model
Browse 1 Ezh2 mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Ezh2
Ezh2, ortholog of human EZH2, encodes the SET domain catalytic subunit of polycomb repressive complex 2, which requires EED and SUZ12 for activity and is allosterically stimulated when the EED aromatic cage binds preexisting H3K27 trimethylation, generating the spreading repressive domains that silence developmental and tumor suppressor loci. Disease alleles run in opposite directions: Y646 substitutions in the SET domain shift substrate preference toward the final trimethylation step and hyperactivate the enzyme in germinal center lymphoma, whereas nonsense and missense loss-of-function mutations occur in myelodysplastic syndrome and T cell leukemia. Model design must reflect this, using a conditional inducible Y646 knockin for lymphoma and inhibitor response work and a conditional null for myeloid loss-of-function questions. Constitutive deletion is embryonic lethal near gastrulation, so Cre-dependent alleles are required, and the paralog Ezh1 sustains residual H3K27 methylation in quiescent and postmitotic tissues, meaning compound Ezh1 deletion may be needed to unmask phenotypes.
What Ezh2 mouse models are available?
ingenious targeting laboratory offers 1 distinct Ezh2 (EZH2) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ezh2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ezh2 allele types
Knockout, conditional, knockin, humanized, and related paths for Ezh2 (human EZH2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ezh2 catalog models
1 Ezh2 line with QC documentation and technical support. Ezh2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Ezh2-Flox
Conditional KnockoutKO/CKO mice, disease model mice
embryo cryopreservationCKO 190022
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Ezh2 (EZH2) from ITL supported projects.
- EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.Beguelin W, Teater M, Gearhart MD, Calvo Fernandez MT, Goldstein RL, Cardenas MG, Hatzi K, Rosen M, Shen H, Corcoran CM, Hamline MY, Gascoyne RD, Levine RL, Abdel-Wahab O, Licht JD, Shaknovich R, Elemento O, Bardwell VJ, Melnick AM. (2016). Cancer Cell 30: 197-213
Looking for a Ezh2 mouse model?
We have 1 Ezh2 model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
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Model Types
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Quote Turnaround
Included
QC Documentation
About Ezh2 Mouse Model Types
A Ezh2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ezh2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ezh2 organized by modification type. Each URL is indexable and matches common search patterns.