Conventional / global / constitutive KO
●1 Model Available
F7 Knockout mouse model
Browse 1 F7 mouse model including knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model F7
F7 encodes coagulation factor VII, the mouse ortholog of human F7 and the trigger protease of the extrinsic pathway. This vitamin K dependent zymogen combines a Gla domain, two EGF-like modules, and a trypsin-like catalytic domain, and a small circulating fraction already exists as factor VIIa that remains essentially inactive until it binds tissue factor exposed by vascular injury or expressed by tumor and myeloid cells; the tissue factor complex allosterically completes the factor VIIa active site, enabling cleavage of factors IX and X and initiation of thrombin generation, with tissue factor pathway inhibitor as the principal check. Complete deficiency permits normal embryogenesis but causes fatal perinatal hemorrhage, so hypomorphic low-expression alleles or conditional deletion with hepatocyte Cre are necessary for adult studies. Patient missense knockins suit factor VII deficiency and bypass therapy questions, while humanized F7 alleles are the correct platform for recombinant factor VIIa and tissue factor directed agent pharmacology.
What F7 mouse models are available?
ingenious targeting laboratory offers 1 distinct F7 (F7) catalog mouse model, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
F7 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
F7 allele types
Knockout, conditional, knockin, humanized, and related paths for F7 (human F7). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available F7 catalog models
1 F7 line with QC documentation and technical support.
- Order
F7-KO
KnockoutKO/CKO mice
embryo cryopreservationKO 225122
Selected publications from ingenious targeting laboratory
Peer reviewed work involving F7 from ITL supported projects.
- TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal developmentTsitsikov EN, Phan KP, Liu Y, Tsytsykova AV, Kinter M, Selland L, Garman L, Griffin C, Dunn IF. (2023). iScience 26(8): 107474
- A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypesVerdone BM, Cicardi ME, Wen X, Sriramoji S, Russell K, Markandaiah SS, Jensen BK, Krishnamurthy K, Haeusler AR, Pasinelli P, Trotti D. (2022). Sci Rep 12(1): 5644
- Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degenerationKevany BM, Zhang N, Jastrzebska B, Palczewski K. (2015). Hum Mol Genet 24(9): 2627-40
Looking for a F7 mouse model?
We have 1 F7 model available — including Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About F7 Mouse Model Types
A F7 knockout mouse has the F7 gene permanently inactivated, enabling loss of function studies.
Modifications available
Jump to catalog backed pages for F7 organized by modification type. Each URL is indexable and matches common search patterns.