Conventional / global / constitutive KO
●3 Models Available
Fas Conditional Knockout, Knockout mouse models
Browse 3 Fas mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Fas conditional knockout mouse, Fas knockout mouse. Request a quote within 24 hours.
Why model Fas
Fas encodes CD95 (APO-1, TNFRSF6), the mouse ortholog of human FAS, a type I membrane death receptor whose three cysteine-rich extracellular domains bind trimeric FAS ligand and whose cytoplasmic death domain, after ligand-driven higher-order clustering, recruits FADD and procaspase-8 into the death-inducing signaling complex to initiate apoptosis directly and through BID cleavage. Outcome depends on receptor palmitoylation, lipid raft clustering, and CFLAR abundance, while non-apoptotic FAS signaling through NF-kappaB and ERK contributes to inflammation and proliferation. Mouse genetics here is historically rich: the lpr allele is a retrotransposon insertion causing aberrant splicing and near-complete loss, lprcg is a death domain point mutation, and both drive lymphadenopathy, autoantibodies, and background-dependent nephritis modeling human autoimmune lymphoproliferative syndrome. Faslg (gld) mutation phenocopies from the ligand side, so the axis is nonredundant. Use conditional flox alleles with T cell, B cell, or hepatocyte Cre for compartment questions and humanization for agonist or antagonist antibody programs.
What Fas mouse models are available?
ingenious targeting laboratory offers 3 distinct Fas (FAS) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fas model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fas allele types
Knockout, conditional, knockin, humanized, and related paths for Fas (human FAS). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fas catalog models
3 Fas lines with QC documentation and technical support. Fas floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Fas (FAS) from ITL supported projects.
- Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon.Saint Fleur S, Hoshino A, Kondo K, Egawa T, Fujii H. (2009). Blood114: 1355-1365
Looking for a Fas mouse model?
We have 3 Fas models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fas Mouse Model Types
A Fas knockout mouse has the Fas gene permanently inactivated, enabling loss of function studies. A Fas conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fas, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Fas organized by modification type. Each URL is indexable and matches common search patterns.