Conventional / global / constitutive KO
●2 Models Available
Fyn Conditional Knockout, Knockout mouse models
Browse 2 Fyn mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Fyn conditional knockout mouse, Fyn knockout mouse. Contact us for availability and fast turnaround.
Why model Fyn
Fyn, mouse ortholog of human FYN, encodes a Src family nonreceptor tyrosine kinase organized as a myristoylated and palmitoylated N-terminal membrane anchor followed by SH3, SH2 and kinase domains, held closed by CSK phosphorylation of the C-terminal tyrosine 531 and opened by CD45 or PTPN22 mediated dephosphorylation with activation loop autophosphorylation. In T cells FYN and LCK phosphorylate CD3 and zeta chain ITAMs to recruit ZAP70, while in neurons the FynB splice isoform phosphorylates NR2B to control NMDA receptor gating and phosphorylates tau at tyrosine 18, placing it downstream of amyloid beta and cellular prion protein signaling in Alzheimer disease models. Nulls are viable with impaired hippocampal long term potentiation and defective thymocyte selection, so constitutive alleles are workable. Src, Yes, Lck and Lyn are genuinely redundant in most lineages, so compound alleles are needed before claiming requirement. Choose conditional nulls for neuronal versus immune assignment and analog-sensitive knockins for acute chemical genetic inhibition.
What Fyn mouse models are available?
ingenious targeting laboratory offers 2 distinct Fyn (FYN) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fyn model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fyn allele types
Knockout, conditional, knockin, humanized, and related paths for Fyn (human FYN). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fyn catalog models
2 Fyn lines with QC documentation and technical support. Fyn floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Fyn mouse model?
We have 2 Fyn models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fyn Mouse Model Types
A Fyn knockout mouse has the Fyn gene permanently inactivated, enabling loss of function studies. A Fyn conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fyn, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Fyn organized by modification type. Each URL is indexable and matches common search patterns.