Conventional / global / constitutive KO
●3 Models Available
Grn Conditional Knockout, Knockout mouse models
Browse 3 Grn mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Grn conditional knockout mouse, Grn knockout mouse. Request a quote within 24 hours.
Why model Grn
Grn, the mouse ortholog of human GRN, encodes progranulin, a secreted cysteine-rich glycoprotein composed of seven and a half granulin repeats that is delivered to lysosomes through sortilin (Sort1) and prosaposin, then proteolytically processed by cathepsins and elastase into individual granulin peptides with activities distinct from the intact precursor. Progranulin regulates lysosomal enzyme function, including glucocerebrosidase and cathepsin D, and restrains microglial activation and complement-driven synaptic pruning. Human genetics defines a dosage logic that should drive allele choice: heterozygous nonsense and frameshift mutations cause frontotemporal dementia with TDP-43 pathology through haploinsufficiency, whereas complete biallelic loss causes neuronal ceroid lipofuscinosis type 11. Null mice are viable and accumulate lipofuscin with age-dependent microgliosis, so germline heterozygotes test haploinsufficiency, full nulls test lysosomal storage, and humanized knockins support progranulin-raising biologics and sortilin-blocking antibodies. No paralog compensates, making dose titration rather than redundancy the central experimental variable.
What Grn mouse models are available?
ingenious targeting laboratory offers 3 distinct Grn (GRN) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Grn model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Grn allele types
Knockout, conditional, knockin, humanized, and related paths for Grn (human GRN). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Grn catalog models
3 Grn lines with QC documentation and technical support. Grn floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Grn mouse model?
We have 3 Grn models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Grn Mouse Model Types
A Grn knockout mouse has the Grn gene permanently inactivated, enabling loss of function studies. A Grn conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Grn, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Grn organized by modification type. Each URL is indexable and matches common search patterns.