Conventional / global / constitutive KO
●1 Model Available
Hes1 Conditional Knockout mouse model
Browse 1 Hes1 mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Hes1
Hes1, the mouse ortholog of human HES1, encodes a basic helix-loop-helix repressor with an Orange domain and a carboxy-terminal WRPW motif that recruits Tle and Groucho corepressors; it is a direct Notch target activated by the NICD and Rbpj complex, binds N-box and class C sites, and represses proneural genes including Ascl1 as well as Cdkn1b, while autorepression of its own promoter combined with rapid protein and mRNA turnover generates two-hour oscillations that time neural progenitor and somite decisions. Homozygous nulls die during embryogenesis with severe neural tube, eye, and pancreatic defects, making conditional alleles essential for postnatal work, and fluorescent or luciferase fusion knockins are the design of choice when the question concerns oscillation dynamics rather than presence or absence. Because Hes5, Hes3, Hey1, and Hey2 provide overlapping repression, single deletions often appear buffered; compound alleles combined with an inducible, lineage-restricted Cre keep the readout aligned with the biology.
What Hes1 mouse models are available?
ingenious targeting laboratory offers 1 distinct Hes1 (HES1) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Hes1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Hes1 allele types
Knockout, conditional, knockin, humanized, and related paths for Hes1 (human HES1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Hes1 catalog models
1 Hes1 line with QC documentation and technical support. Hes1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Hes1-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 240197
Looking for a Hes1 mouse model?
We have 1 Hes1 model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Hes1 Mouse Model Types
A Hes1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Hes1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Hes1 organized by modification type. Each URL is indexable and matches common search patterns.