Conventional / global / constitutive KO
●1 Model Available
Hif1a Conditional Knockout mouse model
Browse 1 Hif1a mouse model including conditional knockout variants — in stock and ready to ship from ingenious targeting laboratory. Request a quote within 24 hours.
Why model Hif1a
Hif1a, the mouse ortholog of human HIF1A, encodes the oxygen-labile alpha subunit of hypoxia-inducible factor 1, a basic helix-loop-helix PAS protein that dimerizes with Arnt and binds RCGTG hypoxia response elements to induce glycolytic enzymes, Slc2a1, Vegfa, and Pdk1. Regulation is post-translational: in normoxia the Egln prolyl hydroxylases modify Pro402 and Pro564 in the oxygen-dependent degradation domain, creating the binding site for the Vhl E3 ligase, while factor inhibiting HIF hydroxylates Asn803 to block p300 recruitment. Homozygous nulls die near E10.5 with vascular and cardiac defects, so conditional deletion is standard for tumor, immunometabolism, and renal studies, whereas a triple knockin substituting both prolines and the asparagine yields an oxygen-insensitive, constitutively active factor that tests whether HIF output alone drives a phenotype. Epas1 encodes Hif2a with overlapping and sometimes antagonistic targets, so isoform-specific compound alleles and a validated driver determine what the readout actually measures.
What Hif1a mouse models are available?
ingenious targeting laboratory offers 1 distinct Hif1a (HIF1A) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Hif1a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Hif1a allele types
Knockout, conditional, knockin, humanized, and related paths for Hif1a (human HIF1A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Hif1a catalog models
1 Hif1a line with QC documentation and technical support. Hif1a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Hif1a-Flox
Conditional KnockoutKO/CKO mice, disease model mice
liveCKO 190065
Looking for a Hif1a mouse model?
We have 1 Hif1a model in stock — including Conditional Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Hif1a Mouse Model Types
A Hif1a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Hif1a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Hif1a organized by modification type. Each URL is indexable and matches common search patterns.