Conventional / global / constitutive KO
●2 Models Available
Hk2 Conditional Knockout, Knockout mouse models
Browse 2 Hk2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Hk2 conditional knockout mouse, Hk2 knockout mouse. Contact us for availability and fast turnaround.
Why model Hk2
Hk2 is the mouse ortholog of human HK2 and encodes the inducible hexokinase of skeletal muscle, heart and adipose tissue, distinguished by two catalytically active halves and by transcriptional induction downstream of insulin, hypoxia through HIF1A, and MYC, which together scale glycolytic entry to demand. Like HK1 it binds VDAC at the outer mitochondrial membrane, an interaction promoted by AKT-dependent phosphorylation that both accelerates glucose phosphorylation and suppresses BAX-dependent apoptosis, giving the protein a survival function alongside catalysis. Tumors frequently depend on this isoform, and Hk2 deletion slows initiation and progression in several models while leaving normal tissues comparatively intact. A conditional null with muscle, adipose or tumor-restricted Cre addresses insulin-stimulated glucose disposal and tumor glycolytic dependence, whereas mitochondrial binding mutant knockins isolate the antiapoptotic role. Since Hk1 remains active in the same tissues, quantify total hexokinase activity, and match allele to clamp studies, fluorodeoxyglucose imaging, or tumor latency endpoints.
What Hk2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Hk2 (HK2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Hk2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Hk2 allele types
Knockout, conditional, knockin, humanized, and related paths for Hk2 (human HK2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Hk2 catalog models
2 Hk2 lines with QC documentation and technical support. Hk2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Hk2 mouse model?
We have 2 Hk2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Hk2 Mouse Model Types
A Hk2 knockout mouse has the Hk2 gene permanently inactivated, enabling loss of function studies. A Hk2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Hk2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Hk2 organized by modification type. Each URL is indexable and matches common search patterns.