Igf1 Knockout mouse models
Igf1, the mouse ortholog of human IGF1, encodes insulin-like growth factor 1, a 70 amino acid peptide generated by signal and E-peptide processing that is produced largely by hepatocytes under growth hormone control and locally by mesenchymal tissues, circulating almost entirely bound to IGFBP3 and IGFALS in a ternary complex that sets bioavailability. Signaling proceeds through IGF1R and, at higher concentrations, insulin receptor hybrids, activating IRS1 to PI3K and AKT for anabolic growth and the SHC to ERK arm for proliferation. Mice lacking Igf1 show severe intrauterine and postnatal growth failure with substantial, strain-dependent perinatal lethality, so conditional alleles are usually preferable, with hepatocyte deletion isolating endocrine IGF-1 from local production and muscle or osteoblast deletion testing autocrine requirements. Humanized alleles enable evaluation of IGF-1 replacement biologics and neutralizing antibodies. Choose the allele to fit the endpoint, whether longitudinal body composition and bone morphometry, growth hormone axis feedback, or lifespan and tissue growth trajectories.
Whole body loss of Igf1 gives the clearest readout when the question is whether the gene is required at all. Follow up tissue work can still move to a conditional allele if lethality or compensation appears.
What Igf1 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Igf1 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Igf1-KO(2) | Knockout | KO/CKO mice | embryo cryopreservation | KO 205037 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Igf1 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Igf1 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Igf1 Knockout mouse models are available?
When Igf1 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Igf1 knockout embryonic lethal in mice?
It depends on background and allele design. Some Igf1 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Igf1 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Igf1?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.