Igf1r Knockout mouse models
The mouse Igf1r locus, ortholog of human IGF1R, specifies a disulfide-linked alpha2beta2 receptor tyrosine kinase that binds IGF-1 and IGF-2, autophosphorylates activation loop, juxtamembrane and C-terminal tyrosines, and recruits IRS1, IRS2 and SHC to drive PI3K to AKT and ERK output, and it also forms hybrid receptors with the insulin receptor that blur ligand specificity in tissues expressing both. Null mice are severely growth retarded and die neonatally of respiratory failure, so viable interrogation requires conditional alleles, with muscle, adipose, neuronal or endothelial Cre lines separating growth, metabolic and vascular contributions and inducible Cre avoiding developmental confounds. Kinase-dead and epitope-humanized knockins address different questions, the former testing scaffold versus catalytic function and the latter enabling preclinical evaluation of IGF1R-directed antibodies and inhibitors whose selectivity against the insulin receptor is the key liability. Because Insr forms hybrids and signals to the same effectors, plan compound Igf1r and Insr alleles before interpreting insulin sensitivity endpoints.
Global Igf1r deletion answers broad mechanism questions quickly. If timing or site matters, conditional alleles are a natural next step after the null is characterized.
What Igf1r Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Igf1r knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Igf1r-KO | Knockout | KO/CKO mice | sperm cryopreservation | KO 205042 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Igf1r Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Igf1r allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Igf1r Knockout mouse models are available?
When Igf1r Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Igf1r knockout embryonic lethal in mice?
It depends on background and allele design. Some Igf1r germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Igf1r animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Igf1r?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.