Conventional / global / constitutive KO
●5 Models Available
Il4 Conditional Knockout, Knockin, Knockout mouse models
Browse 5 Il4 mouse models including conditional knockout, knockin, knockout variants from ingenious targeting laboratory. Available as Il4 conditional knockout mouse, Il4 knockin mouse, Il4 knockout mouse. Contact us for availability and fast turnaround.
Why model Il4
Il4 is the mouse ortholog of human IL4 and encodes the initiating type 2 cytokine, signaling through the type I receptor of IL-4Ralpha with the common gamma chain on lymphocytes and the type II receptor of IL-4Ralpha with IL-13Ralpha1 on myeloid and stromal cells, converging on STAT6 to induce GATA3, immunoglobulin E class switching, and alternative macrophage activation. Its locus lies adjacent to Il13 and Il5 under shared conserved noncoding regulatory elements, so cassette placement can perturb neighbors and generate phenotypes mistakenly attributed to interleukin 4 alone. Because interleukin 4 and interleukin 13 share IL-4Ralpha and STAT6, single nulls give partial results and compound Il4 with Il13 or Il4ra deletion is required for full type 2 collapse. Bicistronic fluorophore reporter knockins mark competent producers without perturbation, while humanization is the appropriate allele for dupilumab-class receptor blockade, and conditional deletion with Cd4-Cre or ILC2 restricted drivers assigns the cellular source.
What Il4 mouse models are available?
ingenious targeting laboratory offers 5 distinct Il4 (IL4) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 5 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Il4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Il4 allele types
Knockout, conditional, knockin, humanized, and related paths for Il4 (human IL4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Il4 catalog models
5 Il4 lines with QC documentation and technical support. Il4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Il4-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 220440 - Order
Il4-IRES-tdTomato
Knockinfluorescent mouse
sperm cryopreservationKI 200028 - Order
Il4-Luc-2A-EGFP
Knockinfluorescent mouse
embryo cryopreservationKI 00021 - Order
Il4-KO(3)
KnockoutKO/CKO mice
sperm cryopreservationKO 233423 - Order
Il4-KO
KnockoutKO/CKO mice
embryo cryopreservationKO 190503
Looking for a Il4 mouse model?
We have 5 Il4 models available — including Conditional Knockout, Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model5
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Il4 Mouse Model Types
A Il4 knockout mouse has the Il4 gene permanently inactivated, enabling loss of function studies. A Il4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Il4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Il4 knockin models carry a precisely inserted sequence at the Il4 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Il4 organized by modification type. Each URL is indexable and matches common search patterns.