What Il4 Conditional Knockout mouse models are available?

When Il4 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is Il4 knockout embryonic lethal in mice?

It depends on background and allele design. Some Il4 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live Il4 animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for Il4?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●5 Models Available

READY TO SHIP!

LIVE · SPERM · EMBRYO

Il4 Conditional Knockout, Knockin, Knockout mouse models

Browse 5 Il4 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Il4 conditional knockout mouse, Il4 knockin mouse, Il4 knockout mouse. Request a quote within 24 hours.

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Why model Il4

Il4 is the mouse ortholog of human IL4 and encodes the initiating type 2 cytokine, signaling through the type I receptor of IL-4Ralpha with the common gamma chain on lymphocytes and the type II receptor of IL-4Ralpha with IL-13Ralpha1 on myeloid and stromal cells, converging on STAT6 to induce GATA3, immunoglobulin E class switching, and alternative macrophage activation. Its locus lies adjacent to Il13 and Il5 under shared conserved noncoding regulatory elements, so cassette placement can perturb neighbors and generate phenotypes mistakenly attributed to interleukin 4 alone. Because interleukin 4 and interleukin 13 share IL-4Ralpha and STAT6, single nulls give partial results and compound Il4 with Il13 or Il4ra deletion is required for full type 2 collapse. Bicistronic fluorophore reporter knockins mark competent producers without perturbation, while humanization is the appropriate allele for dupilumab-class receptor blockade, and conditional deletion with Cd4-Cre or ILC2 restricted drivers assigns the cellular source.

What Il4 mouse models are available?

ingenious targeting laboratory offers 5 distinct Il4 (IL4) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model Availability	Allele Class Options	Quality Control Standards
5 Ready Catalog Lines	Conditional Knockout (cKO)	Documented Germline Transmission
Custom Model Generation	Constitutive Knockout (KO)	Strict United States QC Guidelines
Advanced Modifications	Humanized, Knockin, Transgenic	Cryo or Live Dispatch Options

Quality Control: Documented Germline Transmission
Quality Control: Strict United States QC Guidelines
Quality Control: Cryo or Live Dispatch Options

Il4 model types

PathAvailability

Knockout
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Conditional knockout
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Knockin
View catalog
Humanized
Request a quote
Transgenic / overexpression
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Prefer the order form? Order. Need an allele that is not listed? Request a quote.

Il4 allele types

Knockout, conditional, knockin, humanized, and related paths for Il4 (human IL4). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Conventional / global / constitutive KO

Conditional KO

Inducible conditional KO

Tissue specific KO

Specify tissue or Cre driver on quote

Knockout first

Convertible floxed allele pathway

Double / compound KO

Multi allele / compound knockout project

Large scale / BAC deletion

BAC scale deletion or targeting

Knockin

Point mutation KI

cDNA KI

Reporter KI

Tag KI

Conditional KI

LSL or conditional expression knockin

Gene replacement KI

Humanized

Full gene replacement

Partial / domain humanized

Domain or partial humanization scope

Immune checkpoint humanized

Checkpoint IO humanization when gene is a checkpoint target

Single humanized

Double / multi humanized

Multi humanized / combination IO project

Targeted Transgenic

Safe harbor

Overexpression transgenic

BAC transgenic

BAC transgenic or large fragment insert

Cre / recombinase

Constitutive Cre driver

Inducible Cre

Tamoxifen or dox inducible Cre

Dual recombinase

Dual recombinase breeding scheme

Flp driver

Flp or FRT derivative allele pairing

Reporter

Gene specific reporter knockin

Standalone reporter catalog

Catalog reporter lines not tied to a single gene allele

Species / background

Rat KO / KI / transgenic

Specify rat on quote

Rabbit models

Specify rabbit on quote

C57BL/6

Background substrain on quote

BALB/c

129, NOD, NSG, FVB, CD1, DBA/2

Background strain on quote

Available Il4 catalog models

5 Il4 lines with QC documentation and technical support. Il4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

Il4-Flox
CKO
CKO
These mice carry loxP sites flanking exon 3-4 of Il4 When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Il4 gene.
Sperm CryopreservedCKO 220440
Order
Il4-IRES-tdTomato
KI
Fluorescent Model
A IRES-tdTomato-polyA expression cassette was knocked into the Il4 gene stop codon site.
Sperm CryopreservedKI 200028
Order
Il4-Luc-2A-EGFP
KI
Fluorescent Model
A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon.The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il4.
LiveKI 00021
Order
Il4-KO(3)
KO
KO
The exon 3-4 of Il4 gene was deleted to generate Il4 knockout mouse.
Sperm CryopreservedKO 233423
Order
Il4-KO
KO
KO
Exon 2-4 of Il4 gene was deleted to generate Il4 knockout mice.
Embryo CryopreservedKO 190503
Order

Looking for a Il4 mouse model?

We have 5 Il4 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

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Models Available

Model Types

24 hrs

Quote Turnaround

Included

QC Documentation

About Il4 Mouse Model Types

A Il4 knockout mouse has the Il4 gene permanently inactivated, enabling loss of function studies. A Il4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Il4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Il4 knockin models carry a precisely inserted sequence at the Il4 locus, useful for reporter, tag, or humanization studies.

Knockout Mouse Models Conditional Knockout Mouse Models Knockin Mouse Models Mouse Model Generation Services

Modifications available

Jump to catalog backed pages for Il4 organized by modification type. Each URL is indexable and matches common search patterns.

Il4 Conditional Knockout Il4 Knockin Il4 Knockout Il4 cDNA Knockin Il4 Epitope Tag Knockin Il4 Humanized Il4 Inducible Knockout Il4 Reporter

Related Gene Targets

Il4i1 Il4ra

Breed this line with ingenious targeting laboratory

Send the Il4 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

Live colonies

Il4 models ready to ship

Get a confirmed quote in 24 hours. All Il4 models ship with full QC documentation, health certificates, and lifetime technical support.

Il4Study ready strains in catalog

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Model generation

Need a knockout, knockin, or humanized line?

Specialized conventional and conditional knockouts
Knockins including point mutations, cDNA insertions, and epitope tags
Humanized models, including partial and full gene replacements
Targeted transgenesis in safe harbor loci
Inducible/reversible alleles using advanced recombinase techniques

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 2,800+ custom models generated since 1998. 100% germline transmission guarantee.

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