Conventional / global / constitutive KO
●6 Models Available
Il6 Conditional Knockout, Knockin, Knockout mouse models
Browse 6 Il6 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Il6 conditional knockout mouse, Il6 knockin mouse, Il6 knockout mouse. Request a quote within 24 hours.
Why model Il6
Il6, the mouse ortholog of human IL6, encodes a four-helix bundle cytokine that first binds the nonsignaling Il6ra alpha chain and then recruits two Il6st gp130 molecules to assemble a hexameric complex that activates Jak1 and phosphorylates Stat3, driving Socs3 feedback, hepatic acute phase gene induction, Th17 differentiation with Tgfb, and plasma cell survival. A defining feature is trans-signaling, in which ADAM17-shed soluble Il6ra confers responsiveness on gp130-positive cells lacking the alpha chain, a distinction that shapes allele design: a straight null collapses both arms, an Il6ra conditional or a gp130 chimeric decoy isolates trans-signaling, and humanized IL6 or IL6R knockins are the only credible platform for testing tocilizumab, sarilumab, or siltuximab in vivo. Nulls are viable with blunted acute phase and impaired infection responses, and because Il11, Lif, and Osm also converge on gp130, cytokine-level redundancy should be anticipated when interpreting modest phenotypes.
What Il6 mouse models are available?
ingenious targeting laboratory offers 6 distinct Il6 (IL6) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 6 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Il6 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Il6 allele types
Knockout, conditional, knockin, humanized, and related paths for Il6 (human IL6). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Il6 catalog models
6 Il6 lines with QC documentation and technical support. Il6 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Il6-Flox
Conditional KnockoutKO/CKO mice
liveCKO 220529 - Order
Il6-HiBiT
KnockinotherToolbox of Mice(Non-Cre, fluorescent)
embryo cryopreservationKI 200327 - Order
Il6-Luc-2A-EGFP
Knockinfluorescent mouse
embryo cryopreservationKI 00011 - Order
Il6-2A-DTR-2A-EGFP
Knockinfluorescent mouse, otherToolbox of Mice(Non-Cre, fluorescent)
liveKI 242149 - Order
Il6-KO(2)
KnockoutKO/CKO mice
sperm cryopreservationKO 232813 - Order
Il6-KO
KnockoutKO/CKO mice, disease model mice
liveKO 18029
Looking for a Il6 mouse model?
We have 6 Il6 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model6
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Il6 Mouse Model Types
A Il6 knockout mouse has the Il6 gene permanently inactivated, enabling loss of function studies. A Il6 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Il6, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Il6 knockin models carry a precisely inserted sequence at the Il6 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Il6 organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Il6.