Conventional / global / constitutive KO
●2 Models Available
Irak4 Conditional Knockout, Knockout mouse models
Browse 2 Irak4 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Irak4 conditional knockout mouse, Irak4 knockout mouse. Contact us for availability and fast turnaround.
Why model Irak4
Positioned immediately downstream of MyD88, Irak4 is the mouse ortholog of human IRAK4 and encodes the apical kinase of the Myddosome, using its death domain to assemble a helical oligomer with MyD88 and IRAK1 or IRAK2 and its kinase domain to trigger TRAF6, TAK1, IKK, and MAPK output from all MyD88 coupled TLRs plus IL-1R, IL-18R, and IL-33R. Human IRAK4 deficiency produces narrow but severe susceptibility to pyogenic bacteria that attenuates with age, and MYD88 mutant lymphomas depend on the same complex, providing both loss-of-function and oncology rationales. The decisive allele is the kinase-dead knockin, because it separates catalytic activity from scaffolding and predicts what an active site inhibitor will do, whereas a conditional null predicts the behavior of a heterobifunctional degrader. Add lineage restricted Cre drivers to distinguish myeloid, B cell, and epithelial requirements, and choose humanization when compound selectivity against the human kinase domain is the endpoint.
What Irak4 mouse models are available?
ingenious targeting laboratory offers 2 distinct Irak4 (IRAK4) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Irak4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Irak4 allele types
Knockout, conditional, knockin, humanized, and related paths for Irak4 (human IRAK4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Irak4 catalog models
2 Irak4 lines with QC documentation and technical support. Irak4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Irak4 mouse model?
We have 2 Irak4 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Irak4 Mouse Model Types
A Irak4 knockout mouse has the Irak4 gene permanently inactivated, enabling loss of function studies. A Irak4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Irak4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Irak4 organized by modification type. Each URL is indexable and matches common search patterns.