Conventional / global / constitutive KO
●2 Models Available
Kcnh2 Conditional Knockout, Knockout mouse models
Browse 2 Kcnh2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Kcnh2 conditional knockout mouse, Kcnh2 knockout mouse. Contact us for availability and fast turnaround.
Why model Kcnh2
Kcnh2, the mouse ortholog of human KCNH2, encodes Kv11.1 (ERG1), a voltage-gated potassium channel with an amino-terminal PAS domain and a carboxy-terminal cyclic nucleotide-binding homology domain that interact to set unusually slow deactivation alongside very fast, voltage-dependent C-type inactivation. This gating signature makes ERG1 the carrier of the cardiac rapid delayed rectifier that terminates the action potential plateau, and the same channel regulates firing frequency and spike-frequency adaptation in brain, where KCNH2 variants have been tied to schizophrenia-associated isoforms. Loss-of-function KCNH2 mutations cause long QT syndrome type 2 and the promiscuous inner-cavity binding pocket makes ERG1 the central off-target in drug safety testing. Because mouse ventricular repolarization relies less on this current, humanized knockin alleles that replace the pore and cavity residues are usually more informative than deletion for proarrhythmia work, while conditional nulls address neuronal excitability. Kcnh6 and Kcnh7 form heteromeric ERG channels, so subunit composition should be measured directly.
What Kcnh2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Kcnh2 (KCNH2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Kcnh2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Kcnh2 allele types
Knockout, conditional, knockin, humanized, and related paths for Kcnh2 (human KCNH2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Kcnh2 catalog models
2 Kcnh2 lines with QC documentation and technical support. Kcnh2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Kcnh2 mouse model?
We have 2 Kcnh2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Kcnh2 Mouse Model Types
A Kcnh2 knockout mouse has the Kcnh2 gene permanently inactivated, enabling loss of function studies. A Kcnh2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Kcnh2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Kcnh2 organized by modification type. Each URL is indexable and matches common search patterns.