Conventional / global / constitutive KO
●2 Models Available
Kcnj2 Conditional Knockout, Knockout mouse models
Browse 2 Kcnj2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Kcnj2 conditional knockout mouse, Kcnj2 knockout mouse. Contact us for availability and fast turnaround.
Why model Kcnj2
Kcnj2, the mouse ortholog of human KCNJ2, encodes Kir2.1, the dominant subunit of the strong inward rectifier current IK1 that stabilizes the resting membrane potential of cardiac myocytes, skeletal muscle, and many neurons, and that contributes the terminal phase of cardiac repolarization. Rectification is not intrinsic gating but voltage-dependent block by intracellular magnesium and polyamines at Asp172 and cytoplasmic pore residues, and channel opening requires PIP2, with a Golgi export motif and a PDZ-binding tail controlling trafficking. Loss-of-function and dominant-negative KCNJ2 mutations cause Andersen-Tawil syndrome with periodic paralysis, prolonged QT, and dysmorphic features, whereas gain-of-function alleles cause short QT syndrome type 3, so the design fork is between disease knockin and conditional null. Nulls die neonatally with cleft palate, making cardiac or neuron-restricted conditional deletion necessary for adult work. Kir2.2 and Kir2.3 encoded by Kcnj12 and Kcnj4 heteromerize and blunt single-locus loss, so plan compound genetics for full IK1 collapse.
What Kcnj2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Kcnj2 (KCNJ2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Kcnj2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Kcnj2 allele types
Knockout, conditional, knockin, humanized, and related paths for Kcnj2 (human KCNJ2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Kcnj2 catalog models
2 Kcnj2 lines with QC documentation and technical support. Kcnj2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Kcnj2 mouse model?
We have 2 Kcnj2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Kcnj2 Mouse Model Types
A Kcnj2 knockout mouse has the Kcnj2 gene permanently inactivated, enabling loss of function studies. A Kcnj2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Kcnj2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Kcnj2 organized by modification type. Each URL is indexable and matches common search patterns.