Conventional / global / constitutive KO
●2 Models Available
Kcnq2 Conditional Knockout, Knockout mouse models
Browse 2 Kcnq2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Kcnq2 conditional knockout mouse, Kcnq2 knockout mouse. Contact us for availability and fast turnaround.
Why model Kcnq2
Encoding Kv7.2, Kcnq2 is the mouse ortholog of human KCNQ2 and supplies the principal subunit of the neuronal M current, a slowly activating, noninactivating potassium conductance that opens near threshold and provides the dominant brake on repetitive firing. Kv7.2 assembles preferentially with Kv7.3, requires PIP2 at a carboxy-terminal site and calmodulin at helices A and B, and is targeted to the axon initial segment and nodes of Ranvier through an ankyrin-G binding motif; muscarinic M1 receptor activation depletes PIP2 and suppresses the current, which is the classical mechanism of cholinergic excitation. Human variants split cleanly into loss-of-function alleles causing benign familial neonatal epilepsy and dominant-negative pore mutations causing developmental and epileptic encephalopathy, so patient knockins are essential where deletion is not. Constitutive nulls die perinatally, mandating floxed alleles with Emx1-Cre or Nex-Cre for adult phenotyping. Kcnq3 and Kcnq5 partially substitute, so measure retigabine-sensitive M current directly.
What Kcnq2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Kcnq2 (KCNQ2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Kcnq2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Kcnq2 allele types
Knockout, conditional, knockin, humanized, and related paths for Kcnq2 (human KCNQ2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Kcnq2 catalog models
2 Kcnq2 lines with QC documentation and technical support. Kcnq2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Kcnq2 mouse model?
We have 2 Kcnq2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Kcnq2 Mouse Model Types
A Kcnq2 knockout mouse has the Kcnq2 gene permanently inactivated, enabling loss of function studies. A Kcnq2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Kcnq2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Kcnq2 organized by modification type. Each URL is indexable and matches common search patterns.