Conventional / global / constitutive KO
●2 Models Available
Kcnq5 Conditional Knockout, Knockout mouse models
Browse 2 Kcnq5 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Kcnq5 conditional knockout mouse, Kcnq5 knockout mouse. Contact us for availability and fast turnaround.
Why model Kcnq5
Encoding Kv7.5, Kcnq5 is the mouse ortholog of human KCNQ5 and contributes a slowly activating, noninactivating potassium conductance that co-assembles with Kv7.3 to form a distinct component of the neuronal M current, with particularly strong expression in hippocampal CA3, dentate gyrus, cortical interneurons, auditory brainstem, and in vascular and airway smooth muscle where it sets resting tone. Kv7.5 activates at more negative potentials than Kv7.2-containing channels and is strongly PIP2 dependent and calmodulin regulated, and it is suppressed by Gq-coupled receptor signaling, which converts muscarinic or purinergic input into increased excitability or vasoconstriction. Human KCNQ5 loss-of-function variants cause intellectual disability with or without epilepsy. Nulls are viable, so conditional alleles serve cell-type attribution rather than lethality rescue, and gating knockins test whether the shifted voltage dependence carries the phenotype. Because Kcnq2 and Kcnq3 supply overlapping M current, compound genetics and retigabine-sensitive current measurement should accompany any single-locus interpretation.
What Kcnq5 mouse models are available?
ingenious targeting laboratory offers 2 distinct Kcnq5 (KCNQ5) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Kcnq5 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Kcnq5 allele types
Knockout, conditional, knockin, humanized, and related paths for Kcnq5 (human KCNQ5). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Kcnq5 catalog models
2 Kcnq5 lines with QC documentation and technical support. Kcnq5 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Kcnq5 mouse model?
We have 2 Kcnq5 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Kcnq5 Mouse Model Types
A Kcnq5 knockout mouse has the Kcnq5 gene permanently inactivated, enabling loss of function studies. A Kcnq5 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Kcnq5, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Kcnq5 organized by modification type. Each URL is indexable and matches common search patterns.