Conventional / global / constitutive KO
●1 Model Available
Kdm6a Conditional Knockout mouse model
Browse 1 Kdm6a mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Kdm6a
Chromatin models built on Kdm6a, the mouse ortholog of human KDM6A, must contend with a JmjC domain demethylase (UTX) that removes H3K27me2 and H3K27me3 while serving as a stoichiometric subunit of KMT2D and KMT2C COMPASS-like complexes at enhancers. Loss-of-function truncations recur in bladder carcinoma, T-lineage acute leukemia, and multiple myeloma, and germline variants cause Kabuki syndrome, so the disease-relevant lesion is haploinsufficiency or biallelic inactivation rather than gain of catalysis. Allele planning diverges sharply: a conditional null interrogates enhancer decommissioning and differentiation blockade, a demethylase-dead point knockin separates catalytic from scaffolding function, and humanization supports patient variant interpretation. Redundancy is genuinely load bearing here, because the Y-linked paralog Uty provides catalysis-independent scaffold activity and Kdm6b (JMJD3) overlaps substrate specificity, which explains why hemizygous males survive longer than null females. Since the locus is X-linked and escapes inactivation, sex, dosage, and Cre driver choice (Vav1 or Mx1 versus urothelial Upk2) must be fixed before phenotyping.
What Kdm6a mouse models are available?
ingenious targeting laboratory offers 1 distinct Kdm6a (UTX) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Kdm6a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Kdm6a allele types
Knockout, conditional, knockin, humanized, and related paths for Kdm6a (human KDM6A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Kdm6a catalog models
1 Kdm6a line with QC documentation and technical support. Kdm6a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Kdm6a-Flox
Conditional KnockoutKO/CKO mice, disease model mice
sperm cryopreservationCKO 190054
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Kdm6a (KDM6A) from ITL supported projects.
- UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.Wang C, Lee JE, Cho YW, Xiao Y, Jin Q, Liu C, Ge K. (2012). Proc Natl Acad Sci U S A 109: 15324-15329
Looking for a Kdm6a mouse model?
We have 1 Kdm6a model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
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Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Kdm6a Mouse Model Types
A Kdm6a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Kdm6a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Kdm6a organized by modification type. Each URL is indexable and matches common search patterns.