Conventional / global / constitutive KO
●2 Models Available
Matr3 Conditional Knockout, Knockout mouse models
Browse 2 Matr3 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Matr3 conditional knockout mouse, Matr3 knockout mouse. Contact us for availability and fast turnaround.
Why model Matr3
Matr3, the mouse ortholog of human MATR3, encodes matrin-3, an inner nuclear matrix protein with two RNA recognition motifs, two zinc finger domains, a bipartite nuclear localization signal, and a nuclear export signal, functioning in alternative splicing, nuclear retention of hyperedited RNAs, chromatin organization at matrix attachment regions, and transcription-coupled RNA stability. Matrin-3 binds pyrimidine-rich intronic sequences and physically associates with TDP-43, placing it in the same RNA processing network that fails in amyotrophic lateral sclerosis. The S85C mutation, together with F115C and P154S, causes autosomal dominant ALS with distal myopathy through altered protein stability, mislocalization, and gain of toxic function rather than simple loss, which makes patient knockin alleles the design of record; conditional nulls instead ask whether the protein is required in motor neurons or muscle, since matrin-3 is broadly essential and constitutive deletion is poorly tolerated. Pair knockins with Chat-Cre or muscle drivers as needed, and score splicing, TDP-43 localization, and neuromuscular junction integrity.
What Matr3 mouse models are available?
ingenious targeting laboratory offers 2 distinct Matr3 (MATR3) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Matr3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Matr3 allele types
Knockout, conditional, knockin, humanized, and related paths for Matr3 (human MATR3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Matr3 catalog models
2 Matr3 lines with QC documentation and technical support. Matr3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Matr3 mouse model?
We have 2 Matr3 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Matr3 Mouse Model Types
A Matr3 knockout mouse has the Matr3 gene permanently inactivated, enabling loss of function studies. A Matr3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Matr3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Matr3 organized by modification type. Each URL is indexable and matches common search patterns.