Conventional / global / constitutive KO
●1 Model Available
READY TO SHIP!
DEVELOPING
Med12 Conditional Knockout mouse model
Browse 1 Med12 mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Med12
Med12 encodes the mouse ortholog of human MED12, a subunit of the Mediator kinase module that, together with MED13, cyclin C, and CDK8 or CDK19, docks onto core Mediator to gate RNA polymerase II preinitiation complex activity and to relay Wnt, Notch, and nuclear receptor signals. Recurrent missense and in-frame indel mutations clustered in exons 1 and 2, notably at codon 44, define the overwhelming majority of uterine leiomyomas and also arise in fibroepithelial breast lesions, acting by disrupting kinase module coupling and cyclin C dependent CDK8 stimulation rather than by simple loss. Distinct germline missense variants cause X-linked intellectual disability syndromes including the Opitz-Kaveggia and Lujan phenotypes. Because germline deletion is early embryonic lethal, conditional nulls address transcriptional dependency in defined lineages while precise hotspot knockins are required for leiomyoma modeling and CDK8 inhibitor testing. The paralog Med12l overlaps partially in neural tissue, and X-linkage means sex and Cre selection (for example Amhr2-cre for myometrium) must be predefined.
What Med12 mouse models are available?
ingenious targeting laboratory offers 1 distinct Med12 (MED12) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Med12 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Med12 allele types
Knockout, conditional, knockin, humanized, and related paths for Med12 (human MED12). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Med12 catalog models
1 Med12 line with QC documentation and technical support. Med12 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Med12-Flox
CKOCKO
These mice carry loxP sites flanking exon1-7 of Med12 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Med12 gene.
In DevelopmentCKO 264101
Looking for a Med12 mouse model?
We have 1 Med12 model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Med12 Mouse Model Types
A Med12 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Med12, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Med12 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Med12 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.